DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4a2

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	137/522 - (26%)
Similarity:	237/522 - (45%)	Gaps:	66/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GWLLLAWLYFLWSRRRYY-KVAWQLRG-------PIGWPLIGMGLQMMNPETFLQYMDGLSRQFK 65
            |..||:....|:...::| :..|.|:.       |..| |.|..|:....:..|.:::    :|.
  Rat    21 GAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHW-LWGHNLKDREFQQVLTWVE----KFP 80

  Fly    66 APFISWM-GTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHRRLIN 129
            ...:.|: |::..:.:.||..|:.:|..:....    |:.::..||.||...:..:|.:|||::.
  Rat    81 GACLQWLSGSTARVLLYDPDYVKVVLGRSDPKP----YQSLAPWIGYGLLLLNGKKWFQHRRMLT 141

  Fly   130 PAFGRQILSNFLPIFNAEAEVLLQKLE-LEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMNFQH 193
            |||...||..::.|......::|.|.| |:...|  .|||:..:..:.|:    |.|  |..|.|
  Rat   142 PAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDH--PLEIFHYVSLMTLD----TVM--KCAFSH 198

  Fly   194 DGSLCI-------FKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKV-------VGILFGF 244
            .||:.:       .||...|..:...|:.|.:....:||..|...||.::.       .|.:|
  Rat   199 QGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTGSVF-- 261

  Fly   245 IEQLLEPIVS----VVAANSNPDQQRSEMEMRGKSKAI-FIE-QVREHVERGQ-LSWQDVRDEAN 302
               ||...:|    |:.......|...|::...|.:.: |:: .:...:|.|: ||.:|:|.|.:
  Rat   262 ---LLPAFLSLSDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVD 323

  Fly   303 VTIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINEAMR 367
            ..:....:||::.:.:....||.||.:||:..:|:.:.|.....:..:.|.::.||.|.|.||:|
  Rat   324 TFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALR 388

  Fly   368 LFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSP 432
            |::|||.|.|.....:....|..   ||:|.::.|.||.:..:...| |..:.::| :.|..|||
  Rat   389 LYSPVPSVSRELSSPVTFPDGRS---IPKGIRVTILIYGLHHNPSYW-PNPKVFDP-SRFSPDSP 448

  Fly   433 QRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSY-------RISTEARLEELLVKGNISLK 490
             ||:.|::||:.|.|.|||.::|...:|:.:|.....:       ||........|..|..|.|:
  Rat   449 -RHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLR 512

  Fly   491 LK 492
            ||
  Rat   513 LK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	124/477 (26%)
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	122/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920