DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	239/515 - (46%)	Gaps:	55/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASIILSGWLLLAWLYFLWSRRRYYKVAWQLRG-------PIGWPLIGMGLQMMNPET---FLQY 56
            |..|.|.|.|||.:.    :.:.|.:..|.||.       |..| |.|..||....|.   .|:|
Mouse    19 LQVIFLIGLLLLLFK----AAQHYLRRQWLLRALYQFPSPPSHW-LFGHCLQFKVDEELRWILRY 78

  Fly    57 MDGLSRQFKAPFISWM-GTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPR 120
            ::    :|...|:.|: |:..|:.:.||..::.||.  ....|...|||::..:|.|||..:...
Mouse    79 LE----KFPGAFLHWIWGSHVFIKVCDPDYMKVILG--RADPKASLYRFLTPWLGHGLFFLNGDE 137

  Fly   121 WHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTM 185
            |.:||||:.|||...||..::.|.....:|:|:|.|....| ...|||:..:..::|:    |.|
Mouse   138 WFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQ-DITLEIFHPISLMMLD----TIM 197

  Fly   186 GKKMNFQHDGSL-------CIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFG 243
              |..|.:.||:       ...:|.:.|..:...||.:.:|:.|:||..:...|.......|...
Mouse   198 --KYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHE 260

  Fly   244 FIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIE-QVREHVERG-QLSWQDVRDEANVTIA 306
            ..:::      |....:.....:|..::|||....|:: .:...::.| .||.:.:|.|.:..:.
Mouse   261 HTDRV------VKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMF 319

  Fly   307 ATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAP 371
            ...:|.::.:.:....||.||.:|::..:|:.:.|.....|..:.|.::.||.|.|.||:||:.|
Mouse   320 GGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITWDHLHQMPYTTMCIKEALRLYPP 384

  Fly   372 VPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHA 436
            :|.|.|.....:...  ||..| |:|..:.:..|.:..:.:|| |....::| :.|.::|.| |:
Mouse   385 IPSVGRKLSTPVTFP--DGRSL-PKGITVLLHFYALHHNPKVW-PNPEVFDP-SRFAMNSVQ-HS 443

  Fly   437 FAFVPFTKGLRMCIGYRYAQMLMKLLLA-RIFRSYRISTEARL----EELLVKGNISLKL 491
            .||:||:.|.|.|||...|..::|:.:| .:.|...:...:|:    ::|::|....:.|
Mouse   444 HAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	123/461 (27%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	125/476 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920