DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	523	Identity:	149/523 - (28%)
Similarity:	246/523 - (47%)	Gaps:	55/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASIILSGWLLLAWL---YFLWSRRRYYKVA----WQLRGPIGWPLIGMGLQMMNPETFLQYMDGL 60
            ||:.|:  .:|.|:   |..:.|.|.:...    |      .|..:.|   :.|.|..||.:...
Mouse    27 ASLFLA--RILTWICAFYDNYCRLRCFPEPPSRHW------FWGHMSM---VKNNEEGLQLLTER 80

  Fly    61 SRQFKAPFISWMGTSC-FLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGDGLFTSSSPRWH 122
            |.||....:.|:|... .|.:..|..:..||.::......:  ||.|:...:||||..|:..:|.
Mouse    81 SHQFHDVHLCWIGPFYPILRLIHPKFIGPILQASAAVAPKEMIFYGFLKPWLGDGLLVSAGEKWS 145

  Fly   123 KHRRLINPAFGRQILSNFLPIFNAEAEVL---LQKLELEGVQHGKRLEIYQILKKIVLEAACQTT 184
            :||.|:.|||...||..::..||....::   .|:|..:|.   ..|::.:.:..:.|::.....
Mouse   146 RHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTKGT---ACLDMLEHISLMTLDSLQNCV 207

  Fly   185 MGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLL 249
            .....|.|...|..| .|...|:.:.|||...|:||.|.:|..:...|..:|...::..|.:.::
Mouse   208 FSFDSNCQESPSEYI-AAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVHNFTDAVI 271

  Fly   250 EPIVSVVAANSNPDQQRSEMEMRGKSKAI-FIEQV----REHVERGQLSWQDVRDEANVTIAATF 309
            ......: ::.|.|:   .::.:.|||.: ||:.:    .||.:  :||.:|:|.||:..:....
Mouse   272 RERRRTL-SSQNLDE---FLKSKTKSKTLDFIDVLLLAKDEHGK--ELSDEDIRAEADTFMFGGH 330

  Fly   310 ETTSTALYFTILCLAMHPCYQEKLHKELVTEL----PPSGDINLEQLQRLEYTEMVINEAMRLFA 370
            :||::||.:.:..||.||.|||:..:| |.||    .|. :|..:.|.:|.:..|.|.|::||..
Mouse   331 DTTASALSWILYNLARHPEYQERCRQE-VQELLRGREPQ-EIEWDDLAQLPFLTMCIKESLRLHP 393

  Fly   371 PVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQ-R 434
            ||.::.|...||:.|.  ||. :||:||...|.|:.:..:..|| |....|:| ..|..::|| |
Mouse   394 PVTVISRCCTQDVVLP--DGR-VIPKGTDCVISIFGVHHNPEVW-PDPEVYDP-FRFDPENPQKR 453

  Fly   435 HAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRI----STEARLEELLVKGNISLKLKDYP 495
            ...||:||:.|.|.|||..:|...||:.||.....:|:    ....|..||:::....|.|:..|
Mouse   454 SPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKPELILRAEGGLWLRVEP 518

  Fly   496 LCR 498
            |.:
Mouse   519 LSK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	133/460 (29%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	138/488 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920