DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and cyp-42A1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_507688.2	Gene:	cyp-42A1 / 180236	WormBaseID:	WBGene00013585	Length:	511	Species:	Caenorhabditis elegans

Alignment Length:	497	Identity:	132/497 - (26%)
Similarity:	241/497 - (48%)	Gaps:	21/497 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASIILSGWLLLAW-LYFLWSRRRY-YKVAWQLRGPIGWPLIGMGLQM-MNPETFLQYMDGLSRQF 64
            ||:|:   |.:.| ::|.:.:.:: |......:||...||||...|. .:||.|.:...|::...
Worm     6 ASLIV---LTITWIIHFAFRKAKFIYNKLTVFQGPAALPLIGNFHQFHFSPEEFFEQSQGIAYMM 67

  Fly    65 KA--PFIS--WMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHKHR 125
            :.  ..|:  |:|...|:.:...|.||.||.|....||...|.|:|:.|||||..|...:|...|
Worm    68 RKGDERITRVWLGGLPFVLLYGAHEVEAILGSPKMLNKPFLYGFLSAWIGDGLLISKPDKWRPRR 132

  Fly   126 RLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMN 190
            :|:.|.|...||.:|:.::|.....||.|.|.: ...|:..:::..:....|:..|:..:|..:|
Worm   133 KLLTPTFHYDILKDFVEVYNRHGRTLLSKFEAQ-AGTGEYSDVFHTITLCTLDVICEAALGTSIN 196

  Fly   191 FQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLEPIVSV 255
            .|.|.......|...:.::..:|:|.|..:.|.|:...|..:...:.|.||..|..:.:....:.
Worm   197 AQKDPHSPYLDAVFKMKDIVFQRLLRPHYFSDTIFNLIGPGKEHDECVKILHEFTSKAIYARKAK 261

  Fly   256 VAANSNPDQQRSEMEMRGKSKAIFIEQVREHVERGQLSWQDVRDEANVTIAATFETTSTALYFTI 320
            |.|....:|..::....|:.:..|::.:.:...:|:|..:.:.:|.:.......:|||.|:.:.:
Worm   262 VDAAGGVEQLLAQETAEGRRRMAFLDLMLDMNSKGELPMEGICEEVDTFTFEGHDTTSAAMNWFL 326

  Fly   321 LCLAMHPCYQEKLHKELVTELPPSGD--INLEQLQRLEYTEMVINEAMRLFAPVPMVLRSADQDI 383
            ..:..:|..|.|:.|| :.|:....|  ::.|.|.:|:|.|....|.:||:..||::.|...:||
Worm   327 HLMGANPEIQSKVQKE-IDEVLGEADRPVSYEDLGKLKYLEACFKETLRLYPSVPLIARQCVEDI 390

  Fly   384 QLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFVPFTKGLRM 448
            |: ||   ..:|.||.:.:....:.:|.|.|.. ...:||:..  :....:|.:|::||:.|.|.
Worm   391 QV-RG---HTLPSGTAVVMVPSMVHKDPRYWDD-PEIFNPERF--ITGELKHPYAYIPFSAGSRN 448

  Fly   449 CIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLK 490
            |||.|:|.|..|.:||.|.::.::..:.|.:|:.|...:.::
Worm   449 CIGMRFAMMEEKCILAIILKNLKVKAKLRTDEMRVAAELIIR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	122/447 (27%)
cyp-42A1	NP_507688.2	p450	35..499	CDD:278495	125/465 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920