DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	526	Identity:	151/526 - (28%)
Similarity:	251/526 - (47%)	Gaps:	63/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IILSG--WLL---LAWLYFLW---SRRRYY----KVAWQLRGPIGWPLIGMGLQMMNPETFLQYM 57
            ::|.|  |:|   |||:|..:   ||.|.:    |.:|      .|..:.:   |.|.|..:|::
Mouse    22 LLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSW------FWGHLAL---MKNNEESMQFI 77

  Fly    58 DGLSRQFKAPFISWMG-TSCFLYINDPHSVEQILNSTHCT--NKGDFYRFMSSAIGDGLFTSSSP 119
            ..|...|....:||:| ....|.:..|:.:..:|.::...  .:...|.|:...:||||..|:..
Mouse    78 THLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGD 142

  Fly   120 RWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTT 184
            :|..||||:.|||...||.:::.|||....::..|.:....:...||::::.:..:.|::..:..
Mouse   143 KWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSLQKCI 207

  Fly   185 MGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLL 249
            .....|.|...|..| .|...|:.:.|||...|:||.||:|..:...|..:|...::..|.:.::
Mouse   208 FSVDSNCQESDSKYI-AAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFTDAVI 271

  Fly   250 EPIVSVVAANSNPDQQRSEMEMRG--------KSKAI-FIE-QVREHVERGQ-LSWQDVRDEANV 303
            :             ::||.:..:|        |:|.: ||: .:....|.|: ||.:|:|.||:.
Mouse   272 K-------------ERRSTLNTQGVEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNEDIRAEADT 323

  Fly   304 TIAATFETTSTALYFTILCLAMHPCYQEKLHKELVTEL---PPSGDINLEQLQRLEYTEMVINEA 365
            .:....:||::||.:.:..||.||.|||:..:| |.||   ..|.:|..:.|.:|.:..|.|.|:
Mouse   324 FMFGGHDTTTSALSWILYNLARHPEYQERCRQE-VQELLRDRDSEEIEWDDLAQLPFLTMCIKES 387

  Fly   366 MRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLD 430
            :||..||.::.|...||:.|..|..   ||:|....|.|:.:..:..|| |....||| ..|..:
Mouse   388 LRLHPPVLLISRCCTQDVLLPDGRA---IPKGNICVISIFGVHHNPSVW-PDPEVYNP-FRFDPE 447

  Fly   431 SPQ-RHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE----ARLEELLVKGNISLK 490
            :|| |...||:||:.|.|.|||..:|...:|:.||.....:||..:    .|..||:::....|.
Mouse   448 NPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLW 512

  Fly   491 LKDYPL 496
            |:..||
Mouse   513 LRVEPL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	131/458 (29%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	137/489 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920