DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	132/533 - (24%)
Similarity:	231/533 - (43%)	Gaps:	86/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LASIILSGWLLLA----W-LYFLWSRRRYYKVAWQL-RGPIGWPLIGMGLQM-MNPETFLQYMDG 59
            |.:.:|...|.||    | ||.:.||.|  ..|..| .|.:|:|..|..||| :....|||
  Rat    11 LCTFVLPLLLFLAALKLWDLYCVSSRDR--SCALPLPPGTMGFPFFGETLQMVLQRRKFLQ---- 69

  Fly    60 LSRQ----------FKAPFISWMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLF 114
            :.|:          |..|.:..||..         :|.:||...|......:...:.:.:|.|..
  Rat    70 MKRRKYGFIYKTHLFGRPTVRVMGAD---------NVRRILLGEHRLVSVHWPASVRTILGAGCL 125

  Fly   115 TSSSPRWHKHR-RLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKR-LEIYQILKKIVL 177
            ::.....||.| ::|..||.|:.|..::|:...|....|:    :.:..|:| |.:|..:|:::.
  Rat   126 SNLHDSSHKQRKKVIMQAFNREALQCYVPVIAEEVSGCLE----QWLSCGERGLLVYPEVKRLMF 186

  Fly   178 EAACQTTMGKKMNFQHDG--SLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGI 240
            ..|.:..:|.:......|  ...:.:|:..:|    :.:.|  |..|:.:  |||:| ..|...:
  Rat   187 RIAMRILLGCEPGPAGGGEDEQQLVEAFEEMT----RNLFS--LPIDVPF--SGLYR-GVKARNL 242

  Fly   241 LFGFIEQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAIFIEQVREHV-ERGQ-LSWQDVRDEANV 303
            :...||:.:...:..:.| :.||        .|...|  ::.:.||. |||: |..|.::..:..
  Rat   243 IHARIEENIRAKIRRLQA-AEPD--------AGCKDA--LQLLIEHSWERGERLDMQALKQSSTE 296

  Fly   304 TIAATFETTSTALYFTILCLAMHPCYQEKLHKE-----LVTELPPSGDINLEQLQRLEYTEMVIN 363
            .:....|||::|....|..|.::|...:|:.:|     |:.:......:::|.|::|:|...||.
  Rat   297 LLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIK 361

  Fly   364 EAMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLS--RTYNPDAH 426
            |.:||..|||...|.|.:..:|    ..:.||:|..:   ||::.....|....:  ..:|||..
  Rat   362 ETLRLNPPVPGGFRVALKTFEL----NGYQIPKGWNV---IYSICDTHDVADSFTNKEEFNPDRF 419

  Fly   427 FGLDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKL 491
            ..|.......|:|:||..|||.|:|..:|::|:|:....:.|        |.:..|:.|..::|.
  Rat   420 TSLHPEDTSRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR--------RCDWQLLNGPPTMKT 476

  Fly   492 KD--YPLCRVERR 502
            ..  ||:..:..|
  Rat   477 SPPVYPVDNLPAR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	112/464 (24%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	120/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000