DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	518	Identity:	132/518 - (25%)
Similarity:	231/518 - (44%)	Gaps:	60/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSG---WLLLAWLYFLWSR--RRYYKVAWQLRG-------PIGWPLIGMGLQMMNPETFLQYMDG 59
            :||   |..|..|:.:..:  :.|.:..|.|:.       |..| |.|..|:....:..|.:::
Mouse    15 ISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHW-LWGHHLKDKELQQILIWVE- 77

  Fly    60 LSRQFKAPFISWM-GTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHK 123
               :|.:..:..: |::..:.:.||..|:.:|..:.....| .|:|.:..||.||...:..:|.:
Mouse    78 ---KFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKASG-IYQFFAPWIGYGLLLLNGKKWFQ 138

  Fly   124 HRRLINPAFGRQILSNFLPIFNAEAEVLLQKLE-LEGVQHGKRLEIYQILKKIVLEAACQTTMGK 187
            |||::.|||...||..::.|......::|.|.| |:|..|  .|||:..:..:.|:    |.|
Mouse   139 HRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDH--PLEIFHCVSLMTLD----TVM-- 195

  Fly   188 KMNFQHDGSLCI-------FKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFI 245
            |..|.:.||:.:       .||...|..:...|:.:.:...::||..|...||......|..
Mouse   196 KCAFSYQGSVQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAH--- 257

  Fly   246 EQLLEPIVSVVAANSNPDQQRSEMEMRGKSKAI-FIEQV--REHVERGQLSWQDVRDEANVTIAA 307
                |....|:....:..|...|::...|.:.: |::.:  ....:|..||.:|:|.|.:..:..
Mouse   258 ----EHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFE 318

  Fly   308 TFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPV 372
            ..:||::.:.:....||.||.:|::..:|:.:.|.....:..:.|.::.||.|.|.||:||:.||
Mouse   319 GHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPV 383

  Fly   373 PMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAF 437
            ..|.|.....:....|..   ||:|....|.||.:..:.|.| |..:.::| :.|..|| ..|:.
Mouse   384 ISVSRELSSPVTFPDGRS---IPKGITATISIYGLHHNPRFW-PNPKVFDP-SRFAPDS-SHHSH 442

  Fly   438 AFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE--------ARLEELLVKGNISLKLK 492
            |::||:.|.|.|||.::|...:|:.:|.....:.:..:        ||| .|..|..|.|.||
Mouse   443 AYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARL-VLKSKNGIHLCLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	115/459 (25%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	121/476 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920