DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	516	Identity:	139/516 - (26%)
Similarity:	246/516 - (47%)	Gaps:	36/516 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLASIILSGWLL---LAWLYFLWSRRRYYKVAWQLRGPIGWPLIGMGLQMMNP-ETFLQYMDGLS 61
            :|..::.:.|||   |||.|..:...|..:...|.|.. .|.|..:||  :.| |..|:.:..|.
Human    20 LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQ-NWFLGHLGL--VTPTEEGLRVLTQLV 81

  Fly    62 RQFKAPFISWMG-TSCFLYINDPHSVEQILNSTHCTNKGD--FYRFMSSAIGDGLFTSSSPRWHK 123
            ..:...|:.|:| .:..:.:..|..|..::|::......|  ||:.:...:||||..|...:|..
Human    82 ATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRH 146

  Fly   124 HRRLINPAFGRQILSNFLPIFNAEAEVL---LQKLELEGVQHGKRLEIYQILKKIVLEAACQTTM 185
            ||||:.|||...||..::.||:..|.::   .|:|.:||   ...|::::.:..:.|::..:...
Human   147 HRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEG---STCLDVFEHISLMTLDSLQKCIF 208

  Fly   186 GKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQLLE 250
            ....|.|...|..| .|...|:.:.|||....:.|.|.:|..:...|...:...::..|.:.:::
Human   209 SFDSNCQEKPSEYI-TAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQ 272

  Fly   251 PIVSVVAANSNPDQQRSEMEMRGKSKAI-FIE--QVREHVERGQLSWQDVRDEANVTIAATFETT 312
            .....:.:....|    .::.:.|||.: ||:  .:.|.....:||.:|:|.||:..:....:||
Human   273 ERRRTLTSQGVDD----FLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTT 333

  Fly   313 STALYFTILCLAMHPCYQEKLH---KELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPM 374
            ::.|.:.:..||.||.|||:..   :||:.:..|. :|..:.|.:|.:..|.:.|::||..|:|.
Human   334 ASGLSWVLYNLARHPEYQERCRQEVQELLKDREPK-EIEWDDLAQLPFLTMCLKESLRLHPPIPT 397

  Fly   375 VLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAF 439
            ..|...||:.|.  |.. :||:|....|:|:.:..:..|| |....|:|......::.:|...||
Human   398 FARGCTQDVVLP--DSR-VIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRFDPENAQKRSPMAF 458

  Fly   440 VPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE----ARLEELLVKGNISLKLKDYPL 496
            :||:.|.|.|||.::|...||::||.....:||..:    .|..|::::....|.|:..||
Human   459 IPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	123/453 (27%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	125/467 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920