Protein Alignment Cyp313b1 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_649807.1
• Gene: Cyp313b1 / 41019
• FlyBaseID: FBgn0037601
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 121/471 - (25%)
• Similarity: 199/471 - (42%)
• Gaps: 116/471 - (24%)

  Fly    80 INDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLF------TSSSPRWHKHRRLINPAFGRQILS 138
            :..|.||::.|.||........||.:.:..|:.||      ..:..||||.||:|:.||.|..|.
Human    87 VTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV 151

  Fly   139 NFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAACQTTMGKKMNFQHDGSLCIFKAY 203
            :.:..||.:||.|::                      :|||                     ||
Human   152 SLMETFNEKAEQLVE----------------------ILEA---------------------KA- 172

  Fly   204 NGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGF---IEQLLEPIVSVVAANSN---- 261
            :|.|.|.::.||:   |..:.......|.::   ..:|.|.   :.|.::.::..:.|:.|
Human   173 DGQTPVSMQDMLT---YTAMDILAKAAFGME---TSMLLGAQKPLSQAVKLMLEGITASRNTLAK 231

  Fly   262 --PDQQRSEMEMRGKSKAIFIEQV--------REHVERGQLSWQDV------------RDEANVT 304
              |.:::...|:|...:  |:.||        ||.::||:....|:            .||..:.
Human   232 FLPGKRKQLREVRESIR--FLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLD 294

  Fly   305 IAATF-----ETTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINE 364
            ...||     ||::..|.||::.|:..|....:|..|:...:.....::.|.|.||:|...|:.|
Human   295 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKE 359

  Fly   365 AMRLFAPVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQR-DERVWGPLSRTYNPDAHFG 428
            ::||:.|.....|..:::..:   || ..:|..|.:....|.|.| |.....||  |:||| .||
Human   360 SLRLYPPAWGTFRLLEEETLI---DG-VRVPGNTPLLFSTYVMGRMDTYFEDPL--TFNPD-RFG 417

  Fly   429 LDSPQRHAFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKG-------N 486
            ..:| :..|.:.||:.|.|.|||.::|||.:|:::|::.:        |||..||.|       .
Human   418 PGAP-KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ--------RLEFRLVPGQRFGLQEQ 473

  Fly   487 ISLKLKDYPLCRVERR 502
            .:||..|..||.:..|
Human   474 ATLKPLDPVLCTLRPR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_649807.1	CYP313-like	66..498	CDD:410680	119/465 (26%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	118/464 (25%)