DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313b1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	522	Identity:	149/522 - (28%)
Similarity:	250/522 - (47%)	Gaps:	35/522 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSGWLLLAW-------------LYFLWSRRRYYKVAWQLRGPI-----GWPLIGMGLQMM-NPET 52
            |||..||.|             |..::.....|...||....|     .:||:|..|.|. |...
Mouse     8 LSGQKLLLWGAASAVSLAGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHALYMKPNNAE 72

  Fly    53 FLQYMDGLSRQFK-APFIS-WMGTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFT 115
            |.|.:...:.:|: .|.|. |:|....:.:....:||.||.|:...:|...|:|:...:|.||.|
Mouse    73 FFQQLIYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLT 137

  Fly   116 SSSPRWHKHRRLINPAFGRQILSNFLPIFNAEAEVLLQKLELEGVQHGKRLEIYQILKKIVLEAA 180
            |:..:|...|:::.|.|...||.|||.:.|.:|.:|:.|||....|.......|..|  ..|:..
Mouse   138 STGSKWRTRRKMLTPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITL--CALDII 200

  Fly   181 CQTTMGKKMNFQHDGSLCIFKAYNGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFI 245
            |:|.|||.:..|.:......:....::::..:||..|||:.||.|......|..::.:..|..|.
Mouse   201 CETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFT 265

  Fly   246 EQLL-EPIVSVVAANSNPDQQRSEMEMRGKSKAIFIE---QVREHVERGQLSWQDVRDEANVTIA 306
            ..:: |.:....|........|..:..:.|.|| |::   .|.:. |..:||.:|:|:|.:..:.
Mouse   266 NNVIAERVKERKAEEDWTGAGRGPIPSKNKRKA-FLDLLLSVTDE-EGNRLSQEDIREEVDTFMF 328

  Fly   307 ATFETTSTALYFTILCLAMHPCYQEKLHKELVTELPPS-GDINLEQLQRLEYTEMVINEAMRLFA 370
            ...:||:.|:.:::..|..:|..|.|:.:||......| ..:.||.|::|:|.:.||.|.:|:|.
Mouse   329 EGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFP 393

  Fly   371 PVPMVLRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRH 435
            .||:..||..:|.::    |.:.:.:||:..|..|.:.||.|.: |....:.|:..|..:|..||
Mouse   394 SVPLFARSLSEDCEV----GGYKVTKGTEAIIIPYALHRDPRYF-PDPEEFRPERFFPENSQGRH 453

  Fly   436 AFAFVPFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTEARLEELLVKGNISLKLKDYPLCRVE 500
            .:|:|||:.|.|.|||.::|.|..|.:||.|.|.:.:.:..:.|||.:.|::.|:..:....:::
Mouse   454 PYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWIKLK 518

  Fly   501 RR 502
            ||
Mouse   519 RR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	132/453 (29%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	136/474 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920