DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313b1 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_001287239.1	Gene:	Cyp313b1 / 41019	FlyBaseID:	FBgn0037601	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	509	Identity:	135/509 - (26%)
Similarity:	237/509 - (46%)	Gaps:	46/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSGWL----LLAWLYFLWSRRRYY-KVAWQLRG-------PIGWPLIGMGLQMMNPETFLQYMDG 59
            |||:|    :|..|..|....::| ...|.|:.       |..|   ..|.:....|..|:.:..
Mouse    15 LSGFLQVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHW---FFGHEQFKGEQELKEVVS 76

  Fly    60 LSRQFKAPFISWM-GTSCFLYINDPHSVEQILNSTHCTNKGDFYRFMSSAIGDGLFTSSSPRWHK 123
            ....|.:.|..|. |::.:|.:.||..::.||..:.....| .||.::..||.||...:...|.:
Mouse    77 CIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRSDPKANG-IYRLLAPWIGYGLLLLNGQPWFQ 140

  Fly   124 HRRLINPAFGRQILSNFLPIFNAEAEVLLQKLE-LEGVQHGKRLEIYQILKKIVLEAACQTTMGK 187
            |||::.|||...||..::........::|.|.| |.|  ....:||:|.:..:.|:...:.....
Mouse   141 HRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAG--QDSSIEIFQHISLMTLDTVMKCAFSH 203

  Fly   188 KMNFQHDGSLCIFKAY----NGLTEVCVKRMLSPWLYPDLIYRRSGLFRLQQKVVGILFGFIEQL 248
            |.:.|.||:   :|.|    ..|..:...|:.:.:...|.|||.|...||.::...:.....:
Mouse   204 KGSVQVDGN---YKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHTD-- 263

  Fly   249 LEPIVSVVAANSNPDQQRSEME-MRGKSKAIFIE-QVREHVERG-QLSWQDVRDEANVTIAATFE 310
                 .|:....:..|...|:| ::.|.:..|:: .:...:|.| .:|.:|:|.|.:..:....:
Mouse   264 -----GVIKMRKDQLQDEGELENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHD 323

  Fly   311 TTSTALYFTILCLAMHPCYQEKLHKELVTELPPSGDINLEQLQRLEYTEMVINEAMRLFAPVPMV 375
            ||::.:.:....||.||.:|::..:|:.:.|.....|..:.|.::.||.|.|.||:||:.|||.:
Mouse   324 TTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGI 388

  Fly   376 LRSADQDIQLKRGDGEFLIPRGTQIGIDIYNMQRDERVWGPLSRTYNPDAHFGLDSPQRHAFAFV 440
            :|.....:...  ||..| |:|.|:.:.||.:..:.:|| |....::| :.|..||| ||:.:|:
Mouse   389 VRELSTSVTFP--DGRSL-PKGVQVTLSIYGLHHNPKVW-PNPEVFDP-SRFAPDSP-RHSHSFL 447

  Fly   441 PFTKGLRMCIGYRYAQMLMKLLLARIFRSYRISTE-ARLEELLVKGNISLKLKD 493
            ||:.|.|.|||.::|...:|:::|.....:.:..: .|:.|.|.:  |.||.|:
Mouse   448 PFSGGARNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLAR--IVLKSKN 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313b1	NP_001287239.1	p450	33..474	CDD:299894	118/456 (26%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	125/472 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920