Protein Alignment 5-HT2B and htr2cl2

DIOPT Version :9

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_001339040.4
• Gene: htr2cl2 / 798599
• ZFINID: ZDB-GENE-120215-109
• Length: 348
• Species: Danio rerio
• Alignment Length: 848
• Identity: 151/848 - (17%)
• Similarity: 233/848 - (27%)
• Gaps: 504/848 - (59%)

  Fly    50 VARWNATGNATISATFEDVPFDANNYW-ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLM 113
            :|..|.|.:..::     :..|.:..| ||..||::..|.||||||.:|::.|.:|.|.||:||.
Zfish     1 MALLNTTASCNVT-----LDTDHSYSWPALFILVIIFFTIAGNILVIMAVSIESKLHNPTNFFLC 60

  Fly   114 SLAITDLMVAVLVMPLGILTLVKGY-FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRY 177
            |||:.|::|..||||:.:::::..: :||....|..||.|||||.||||||||.||:|||:.:|.
Zfish    61 SLAVADMLVGFLVMPISLISILYNHTWPLPQLLCPLWIFLDVLFSTASIMHLCAISLDRYIGIRN 125

  Fly   178 PMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFY 242
            |......::.|:..:||:.||.:||.:|||:.:|..::...|.::..|.:.:|.:.||||||.|:
Zfish   126 PFSISHTQSSRKAMIKIITVWTISIVLSLPIPVMGLQDEQKVFIDCACVLNEPRFILVGSIVAFF 190

  Fly   243 IPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNA 307
            :||.:|::.|.||
Zfish   191 VPLVIMVVCYYLT---------------------------------------------------- 203

  Fly   308 SSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTT 372
                                                     ||
Zfish   204 -----------------------------------------LH---------------------- 205

  Fly   373 GSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTT 437
                        |||            .|.:|..|:
Zfish   206 ------------HLQ------------KHSKSFPHD----------------------------- 217

  Fly   438 TLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVET 502
                                                                             
Zfish   218 ----------------------------------------------------------------- 217

  Fly   503 PTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKA 567
                                                           :||...||..|
Zfish   218 -----------------------------------------------SKSSCMHSSIE------- 228

  Fly   568 KQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMEL 632
                                                              |:.|:..:|.|..::
Zfish   229 --------------------------------------------------TSDTSFLNSKSSSKM 243

  Fly   633 LMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCP 697
                                                                             
Zfish   244 ----------------------------------------------------------------- 243

  Fly   698 GRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMN 762
                                                           |:.|:.:.:.|:|.|.||
Zfish   244 -----------------------------------------------SAFPVIKRSPLKSRQGMN 261

  Fly   763 YQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFT 827
                                                          |.:..|::|:||||:|||.
Zfish   262 ----------------------------------------------RALENERRASKVLGIVFFL 280

  Fly   828 FVILWSPFFVLNLLPTVCAE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLL 891
            |:|:|.|||:.|:|..:|.: |.|.: |.:.|:..|:||.||.|||:.||:|||.:||||.:.|.
Zfish   281 FLIMWCPFFITNVLNAICRDNCSEYV-HKLLDIFVWVGYVSSGVNPLIYTLFNKTYRQAFARYLR 344

  Fly   892 CRY 894
            |::
Zfish   345 CKF 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	74/172 (43%)
		7tm_4	90..>238	CDD:304433	64/148 (43%)
htr2cl2	XP_001339040.4	7tm_4	26..>159	CDD:304433	61/132 (46%)
		7tm_1	37..328	CDD:278431	129/786 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136698
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2797
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408957at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24235
orthoMCL	1	0.900	-	-		OOG6_109260
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970