DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and htr1ab

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001139238.1 Gene:htr1ab / 797538 ZFINID:ZDB-GENE-090409-2 Length:403 Species:Danio rerio


Alignment Length:872 Identity:155/872 - (17%)
Similarity:228/872 - (26%) Gaps:481/872 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 EEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILV 94
            |.::|.....|.:...:|        |.|.|:..   .||.......:||...|:|.:..||..|
Zfish     3 ENNDTSFLFQNDSDLDHQ--------TDNVTLPV---KVPLSYQISTSLLIGALILCSIFGNACV 56

  Fly    95 CLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTA 159
            ..|||.||.||||.||.:.|||:|||||:|||:|:..|..|...:.||...|..:|.||:|.||:
Zfish    57 VAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLDKWTLGQVTCDIFISLDILCCTS 121

  Fly   160 SIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGT 224
            ||:|||.|::|||.::..|:.:.:.:|.:|..|.|...|.:..::|:|..|:......      |
Zfish   122 SILHLCAIALDRYWAITDPIDYMKKRTLKRAALLITVTWFVGFSISIPPMLIMKSQPK------T 180

  Fly   225 CQIP-DPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAP 288
            |.|. ||.|.:..:...|||||.:||:.|                             |.:.:|.
Zfish   181 CMISHDPWYTIYSTFCAFYIPLILMLVLY-----------------------------GRIFKAA 216

  Fly   289 ALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFG 353
            ....|.|.|:                                                       
Zfish   217 RFRIRKTVRK------------------------------------------------------- 226

  Fly   354 AEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYH 418
                                                    |:                       
Zfish   227 ----------------------------------------PE----------------------- 228

  Fly   419 QQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSA 483
                                                                    |||.:..:.
Zfish   229 --------------------------------------------------------KKRVKCLTV 237

  Fly   484 VPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKN---ALYPRHTTVQESLDDDDDEEEESAQQ 545
            .|...|||..|                     |.||   |:.|:                     
Zfish   238 SPALFKRANGE---------------------LSKNWKSAVEPK--------------------- 260

  Fly   546 KDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKII 610
                                                   |:.|         :...:|.||    
Zfish   261 ---------------------------------------PAAC---------VNGAIKHAE---- 273

  Fly   611 SSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQ 675
                                                                            .
Zfish   274 ----------------------------------------------------------------D 274

  Fly   676 GSSL---TVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPT 737
            |.||   .|.|:....|..|.||                                          
Zfish   275 GESLEIIEVHSNSKNNLPLPNTP------------------------------------------ 297

  Fly   738 KTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISR 802
                   :|.||                                       ..:.|.:|:     
Zfish   298 -------NSVPL---------------------------------------FENKHEKNT----- 311

  Fly   803 NSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYAS 867
             .::....:..|:|..|.||::..||::.|.|||:..|:...|..|...:  |:.||:.||||::
Zfish   312 -EAKRKLALARERKTVKTLGIIMGTFILCWLPFFIKALVMPFCPTCVMPL--WLQDVINWLGYSN 373

  Fly   868 SMVNPIFYTIFNKVFRQAFKKVLLCRY 894
            |::|||.|..|||.|:.||||::.|.:
Zfish   374 SLLNPIIYAYFNKDFQSAFKKIIKCHF 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 73/193 (38%)
TM helix 1 75..101 CDD:320433 10/25 (40%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 6/22 (27%)
TM helix 5 229..258 CDD:320433 11/28 (39%)
7tm_GPCRs <799..893 CDD:475119 34/93 (37%)
TM helix 6 818..840 CDD:410628 9/21 (43%)
TM helix 7 854..879 CDD:410628 12/24 (50%)
htr1abNP_001139238.1 7tm_GPCRs 36..392 CDD:475119 141/818 (17%)
TM helix 1 38..62 CDD:320453 9/23 (39%)
TM helix 2 71..93 CDD:320453 14/21 (67%)
TM helix 3 109..131 CDD:320453 12/21 (57%)
TM helix 4 154..170 CDD:320453 4/15 (27%)
TM helix 5 187..210 CDD:320453 10/51 (20%)
TM helix 6 326..348 CDD:320453 9/21 (43%)
TM helix 7 360..385 CDD:320453 12/26 (46%)

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