Protein Alignment 5-HT2B and htr2b

DIOPT Version :9

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 877
• Identity: 161/877 - (18%)
• Similarity: 250/877 - (28%)
• Gaps: 523/877 - (59%)

  Fly    71 DANNYW-ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILT- 133
            |..::| |||.|::::.|..|||||.||::.||:|||.||:||||||:.||:|.:||||:.::|
Zfish    11 DWPSHWAALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTV 75

  Fly   134 LVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVW 198
            |....:||....|..|:.|||||.||||||||.||:|||::::.|::..:.|:|.:|..||..||
Zfish    76 LYNSTWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVW 140

  Fly   199 LLSIAMSLPL-----------SLMYSKNHASVLVNGTCQI-PDPV--YKLVGSIVCFYIPLGVML 249
            |:||.:::|:           ::.::|||       ||.: |:..  :|:.||:|.|:|||.:|:
Zfish   141 LISIGIAIPIPIKGLQFFDHPNITFNKNH-------TCLLSPEGFRDFKVYGSLVAFFIPLAIMM 198

  Fly   250 LTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAH 314
            :.|.||:::|
Zfish   199 IIYLLTIQVL------------------------------------------------------- 208

  Fly   315 SANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSE 379
                                                                             
Zfish   209 ----------------------------------------------------------------- 208

  Fly   380 FSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERE 444
                                                                             
Zfish   209 ----------------------------------------------------------------- 208

  Fly   445 STRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRR 509
                                     |.:||..|.||:.
Zfish   209 -------------------------RKKAYLLRSRAAR--------------------------- 221

  Fly   510 HKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAG 574
                                                                             
Zfish   222 ----------------------------------------------------------------- 221

  Fly   575 QNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGN 639
                      ||:.|            |...|:.:::|.                 |.::.|:|.
Zfish   222 ----------PSIST------------VFQQELSVLASP-----------------EKMVISNGI 247

  Fly   640 KKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSI 704
            |:..|.:....|||
Zfish   248 KRDRTLNPVNPITG--------------------------------------------------- 261

  Fly   705 SKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATL--RSHQNMNYQGAG 767
                                                    ...||||.:|:  ||.||:..
Zfish   262 ----------------------------------------DEVPLRRMSTIGKRSMQNLTN---- 282

  Fly   768 ECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILW 832
                                                          ||:|:||||:||..||::|
Zfish   283 ----------------------------------------------EQRASKVLGIVFMLFVVMW 301

  Fly   833 SPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSST 897
            .|||:.|:...:|..|...:...:.|:..|:||.||.:||:.||:||:.||.||::.:.|.|.|.
Zfish   302 CPFFITNVTSVLCERCNGNLVDQLLDIFQWVGYVSSGINPLVYTLFNRTFRLAFRRYITCNYKSV 366

  Fly   898 SAWRPSRXQTPVKPGKLKTNTHKCASVDFQDS 929
                    :||    ||:    :.:.:.|:.|
Zfish   367 --------RTP----KLQ----RRSKISFRSS 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	82/186 (44%)
		7tm_4	90..>238	CDD:304433	71/162 (44%)
htr2b	NP_001038208.1	7tm_1	31..344	CDD:278431	137/801 (17%)
		7tm_4	31..>211	CDD:304433	83/396 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2797
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408957at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24235
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970