Protein Alignment 5-HT2B and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 960
• Identity: 454/960 - (47%)
• Similarity: 541/960 - (56%)
• Gaps: 230/960 - (23%)

  Fly    49 HVARWNATGNATISATFEDV-----PFDA------------NNYWALLALVLVLGTAAGNILVCL 96
            ::.::|.|||...:.|..:.     ..||            :|||||||::||.|||||||||||
Mosquito    73 YMKQFNFTGNPIDNRTGAEAGLGPDRIDADDDEDDGSSLALHNYWALLAIILVFGTAAGNILVCL 137

  Fly    97 AIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASI 161
            ||.||||||||||||||||||||||||:.||||||||||||:|||.||:||.|||||||||||||
Mosquito   138 AIVWERRLQNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYCLVWICLDVLFCTASI 202

  Fly   162 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQ 226
            ||||||||||||||||||:||||||||||.|||.||||||||||||||||||||||||||:||||
Mosquito   203 MHLCTISVDRYLSLRYPMKFGRNKTRRRVVLKISFVWLLSIAMSLPLSLMYSKNHASVLVDGTCQ 267

  Fly   227 IPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALE 291
            |||||||||||||||||||.|||:||.|||||||:|.:||||    ..:..||:|||||||||.:
Mosquito   268 IPDPVYKLVGSIVCFYIPLCVMLITYTLTVRLLAQQSENLGG----VGSGGGWSSGWLGQAPAFD 328

  Fly   292 RRCTWRRLLK---PGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFG 353
            ||.||:|::|   |...|.    |||||.||||:|||||||:|||.:|||.||:..||||:.:||
Mosquito   329 RRNTWKRIIKLSLPAAQNP----HAHSAASTDTELSTLDNHDLWLLESSIPEPSSITMTAMQRFG 389

  Fly   354 AEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYH 418
            .||||||:||||||                                        .|....:|...
Mosquito   390 EEMLKLSQGLESVA----------------------------------------QHSDRNSGQNG 414

  Fly   419 QQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSA 483
            ...||:...              |:||.|...|:::    .:...::.::.|.....|:||:|::
Mosquito   415 SSRSPEPSR--------------EKESFRKKPANAK----HAPTPVTMVTVRSPVPSKKRRSSTS 461

  Fly   484 VPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQ--- 545
            .....:.:|         ||.......||..||| :||.|       ...||.:.:|:..|.
Mosquito   462 TWIARRNSG---------TPPPVRLVRKRFKSLP-HALPP-------PASDDIEVDEQFMQDVLY 509

  Fly   546 --KDQQTKSKICHSDTE-----LD---------------------PPQKAKQCH-IAGQNHQSDY 581
              :|::.:..:..|...     ||                     .|...:|.| :|..:..:..
Mosquito   510 ELRDREDRGSVHGSSARPGAAGLDGVPAAASRATSDRREGRDAGSNPAGPRQAHPLAAPSQTAAT 574

  Fly   582 LQLPSVCTCPYFGDRP--LQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644
            |:||..|.||:||:..  .|..::.||:||:.
Mosquito   575 LKLPPPCKCPFFGEGAPGRQQYLRPAEIKIVK--------------------------------- 606

  Fly   645 SSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQ-----SDGSGYLAAPGTPCPGRRKLSI 704
            :|...|..||.|....:.|.||:|..|    ||::|.|     |.....|.|.....|. ||.|.
Mosquito   607 TSTDFGPMGGAASNGDSLVYSTISISS----GSNVTTQPTRSISSSLSTLPASALASPS-RKGSA 666

  Fly   705 SKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGEC 769
            .|..||||||..||:||||||||.||||||||||   .|.||..||||..|| |..:...|.|..
Mosquito   667 PKGISVVTWDQRRHQRRGSSFGGARTSLLLTPTK---ASPSSVSLRRSINLR-HSALEGGGGGGG 727

  Fly   770 G--------GKTRTTTSSPCMLQRQ-------------------------------------QTV 789
            |        |..:..:||||::|.|                                     ..|
Mosquito   728 GSAGETMFRGAPKKNSSSPCLMQHQTGGGGGGGAVGGGNGTAVAMMAVAAASSTVPTLATTTMAV 792

  Fly   790 RSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISH 854
            |||||||||:|||||||||||||||||||||||||||||||||:|||||||||:||..||:.|..
Mosquito   793 RSHHSRNSSMISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWAPFFVLNLLPSVCKHCEDNIDQ 857

  Fly   855 WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYS-STSAWRPS 903
            |||:.|||||||||:|||||||||||.||.||:|||||||. ....|:|:
Mosquito   858 WVFEFVTWLGYASSLVNPIFYTIFNKAFRDAFRKVLLCRYGLKARHWQPN 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	172/192 (90%)
		TM helix 1	75..101	CDD:320433	21/25 (84%)
		TM helix 2	108..134	CDD:320433	23/25 (92%)
		TM helix 3	146..176	CDD:320433	28/29 (97%)
		TM helix 4	188..211	CDD:320433	20/22 (91%)
		TM helix 5	229..258	CDD:320433	25/28 (89%)
		7tm_GPCRs	<799..893	CDD:475119	78/93 (84%)
		TM helix 6	818..840	CDD:410628	20/21 (95%)
		TM helix 7	854..879	CDD:410628	20/24 (83%)
5-HT2B	XP_061501050.1	None