Protein Alignment 5-HT2B and htr7a

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_021328829.2
• Gene: htr7a / 562111
• ZFINID: ZDB-GENE-130530-666
• Length: 479
• Species: Danio rerio
• Alignment Length: 822
• Identity: 134/822 - (16%)
• Similarity: 198/822 - (24%)
• Gaps: 492/822 - (59%)

  Fly    82 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMP-LGILTLVKGYFPLGSEH 145
            :|.|.|..||:||.:::.:.::|:..:||.::|||:.||.||:.||| :.|..|:.|.:..|...
Zfish   113 MLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSITDLIGGRWIFGKFF 177

  Fly   146 CLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSL 210
            |..:|.:||:.||||||.||.||:||||.:..|:.:...:....:...::.|||||.:::||...
Zfish   178 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLSVWLLSASITLPPLF 242

  Fly   211 MYSKNHASVLVNG--TCQI-PDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQT 272
            .:::|     ||.  .|.| .|..|.:..:.|.||||:.|||:.|....|
Zfish   243 GWAQN-----VNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFR--------------- 287

  Fly   273 AAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSS 337
             ||
Zfish   288 -AA-------------------------------------------------------------- 289

  Fly   338 IKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQ 402
                                |||                                     ||.|
Zfish   290 --------------------KLS-------------------------------------AAKH- 296

  Fly   403 QSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQL 467
                                       |:.|
Zfish   297 ---------------------------TITG---------------------------------- 300

  Fly   468 SQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESL 532
                                                                  :||  ..||.:
Zfish   301 ------------------------------------------------------FPR--VEQEEV 309

  Fly   533 DDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFG--- 594
            ::|:.||:                                     ..|..:.|:...|....
Zfish   310 EEDEVEED-------------------------------------GGDGAEEPTGVDCVTVAIKL 337

  Fly   595 DRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAA 659
            .|.::.|.:...:
Zfish   338 QREVEECARLPRI---------------------------------------------------- 350

  Fly   660 PATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSS 724
                                         |...|..|..||.:||.|.
Zfish   351 -----------------------------LRGVGRRCSDRRSISIFKR----------------- 369

  Fly   725 FGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTV 789
                                                                             
Zfish   370 ----------------------------------------------------------------- 369

  Fly   790 RSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLL-PTVC-AECEERI 852
                                    ||||...||:|...|.|.|.|||:|:.. |.:| .|| ..|
Zfish   370 ------------------------EQKAAATLGIVVGAFTICWLPFFLLSTARPFICGTEC-SCI 409

  Fly   853 SHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRY 894
            ..||...:.|||||:|::||..|..||:..|..::.:|.|||
Zfish   410 PLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLSCRY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	67/188 (36%)
		TM helix 1	75..101	CDD:320433	7/18 (39%)
		TM helix 2	108..134	CDD:320433	13/26 (50%)
		TM helix 3	146..176	CDD:320433	18/29 (62%)
		TM helix 4	188..211	CDD:320433	7/22 (32%)
		TM helix 5	229..258	CDD:320433	11/28 (39%)
		7tm_GPCRs	<799..893	CDD:475119	34/95 (36%)
		TM helix 6	818..840	CDD:410628	10/21 (48%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)
htr7a	XP_021328829.2	None