DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2B and htr2ab

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:XP_009300470.1 Gene:htr2ab / 559806 ZFINID:ZDB-GENE-120215-60 Length:458 Species:Danio rerio


Alignment Length:855 Identity:157/855 - (18%)
Similarity:234/855 - (27%) Gaps:514/855 - (60%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 GNATIS-------------ATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVT 108
            |||.::             :.|....:...|:.|||..::::.|..|||||.:|::.||:|||.|
Zfish    32 GNAVLNNSMDCNGSEERNRSEFSSSDYVQKNWVALLISLVIIITVTGNILVIMAVSLERKLQNAT 96

  Fly   109 NYFLMSLAITDLMVAVLVMPLGILTLVKGY-FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRY 172
            ||||.||||||:::.:||||:.::|::.|| :||....|..||.|||||.||||||||.||:|||
Zfish    97 NYFLRSLAITDMLLGILVMPVAMVTILYGYTWPLPRTLCPIWIYLDVLFSTASIMHLCAISLDRY 161

  Fly   173 LSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGS 237
            :::|.|:...|:.:..:..:||:..|.:|:.:|:|:.::...:|:.|..|.:||:.|..:.|:||
Zfish   162 IAIRNPIHHSRSNSLTKARVKIIAAWTISVVISMPVPVLGLHDHSKVFRNESCQLTDNNFVLIGS 226

  Fly   238 IVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKP 302
            .|.|::||.:|::||.||:..|                                           
Zfish   227 FVAFFVPLIIMVVTYFLTISAL------------------------------------------- 248

  Fly   303 GPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVA 367
                                                                             
Zfish   249 ----------------------------------------------------------------- 248

  Fly   368 SSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVL 432
                                                                             
Zfish   249 ----------------------------------------------------------------- 248

  Fly   433 GLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDAD 497
                                      ||:.||.                              .|
Zfish   249 --------------------------QSEATLC------------------------------LD 257

  Fly   498 EDVETPT--STLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTE 560
            :.:..||  ||:            .|.||.:...|.|                .::|.||     
Zfish   258 QLIVRPTWSSTI------------GLLPRGSVSSERL----------------FSRSSIC----- 289

  Fly   561 LDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSS 625
                                                                             
Zfish   290 ----------------------------------------------------------------- 289

  Fly   626 SPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLA 690
                                                                             
Zfish   290 ----------------------------------------------------------------- 289

  Fly   691 APGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATL 755
                                         |.|:|.|..|.|:                       
Zfish   290 -----------------------------REGASRGSGRRSM----------------------- 302

  Fly   756 RSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKV 820
                                           |::.:                      ||||:||
Zfish   303 -------------------------------QSISN----------------------EQKASKV 314

  Fly   821 LGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQ 884
            |||||..|||:|.||||.|::..||.. |:|.:...:.:|..|:||.||.|||..||:|||.:|.
Zfish   315 LGVVFLLFVIMWCPFFVTNVMAVVCGSVCDEDLVGGLMNVFVWVGYLSSAVNPFIYTLFNKTYRA 379

  Fly   885 AFKKVLLCRY 894
            ||.:.:.|||
Zfish   380 AFARYMQCRY 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 85/193 (44%)
TM helix 1 75..101 CDD:320433 10/25 (40%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 6/22 (27%)
TM helix 5 229..258 CDD:320433 13/28 (46%)
7tm_GPCRs <799..893 CDD:475119 41/94 (44%)
TM helix 6 818..840 CDD:410628 15/21 (71%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
htr2abXP_009300470.1 7tm_GPCRs 62..381 CDD:475119 148/815 (18%)
TM helix 1 64..88 CDD:410628 10/23 (43%)
TM helix 2 97..119 CDD:410628 14/21 (67%)
TM helix 3 136..158 CDD:410628 16/21 (76%)
TM helix 4 181..197 CDD:410628 5/15 (33%)
TM helix 5 219..242 CDD:410628 9/22 (41%)
TM helix 6 312..334 CDD:410628 15/21 (71%)
TM helix 7 349..374 CDD:410628 11/24 (46%)

Return to query results.
Submit another query.