DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT2B and Oamb

DIOPT Version :9

Sequence 1:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	194/898 - (21%)
Similarity:	308/898 - (34%)	Gaps:	301/898 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRL 104
            |.|...:.:...:|....|....|..|.:.            |||:|   ||.||..|:....:|
  Fly     2 NETECEDLIKSVKWTEPANLISLAVLEFIN------------VLVIG---GNCLVIAAVFCSNKL 51

  Fly   105 QNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISV 169
            ::|||:|:::||:.||:|.:.|:|......|...:..|...|..|:.:||..|||||::||.||:
  Fly    52 RSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISL 116

  Fly   170 DRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKL 234
            |||:::..|:.:....:.::....|..:|:||..:..| .|:..|:..:|:        .|.|
  Fly   117 DRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP-PLVGWKDQKAVI--------QPTY-- 170

  Fly   235 VGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRL 299
                     |.|...|.|  |..:.:.:...||   ..:....|.||
  Fly   171 ---------PKGNHTLYY--TTTMSSSEDGQLG---LDSIKDQGEAS------------------ 203

  Fly   300 LKPGP---GNASSVLHAHSANSTDTDLSTLD-NHELWLP--DSSIKEPTPTTMTALHQFGAEMLK 358
            |.|.|   ||.::.      |..|...:.:| :.|:.:.  ||:....|.||.|
  Fly   204 LPPSPPHIGNGNAY------NPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTT----------- 251

  Fly   359 LSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASP 423
                  :.:|||||  .|:.:..|.|                                    |.|
  Fly   252 ------TASSSSTT--ETEMDLDLLN------------------------------------APP 272

  Fly   424 KGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAV-PGR 487
            :.| ..|:.|  :.....|..:.|..:..|.:|..... ....|....|.|:...|.:.|: .|.
  Fly   273 QNR-PQTISG--SCPWKCELTNDRGYVLYSALGSFYIP-MFVMLFFYWRIYRAAVRTTRAINQGF 333

  Fly   488 EKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKS 552
            :...|.:......|....|||.|:...|..:::::...:|                    |.|
  Fly   334 KTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGST--------------------QST-- 376

  Fly   553 KICHSDTELDPPQKAKQCHIAGQN-HQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRV 616
                 .|.|..|...:....|.:. |..|                         ::||
  Fly   377 -----TTTLGTPSPERLSKYATRRLHHHD-------------------------KIKI------- 404

  Fly   617 TTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSL-T 680
               :.:..||.:..||                         |....||     |.....|::| .
  Fly   405 ---SVSYPSSENISEL-------------------------AGHGDVG-----HERRQSGNALFA 436

  Fly   681 VQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLL-----TPTKTA 740
            |..:|:.          ||     ..|.|.:.....:|        ||.:|..|     .|....
  Fly   437 VHYNGTN----------GR-----ESTESQLYRQQQQH--------GVASSCYLQVGKGLPELAR 478

  Fly   741 TTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSR--NSSVISRN 803
            ..||:|                     |.||                   |.|||  |..:..||
  Fly   479 RQSNTS---------------------EAGG-------------------SGHSRPANKKMGRRN 503

  Fly   804 SSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASS 868
            .....:..|:|.||.|.|.::...|:..|.|||.:.::...|.:|.:.:   :|.|:.||||.:|
  Fly   504 IKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPL---LFSVLFWLGYCNS 565

  Fly   869 MVNPIFYTIFNKVFRQAFKKVL---LCRYSSTSAWRPSRXQTPVKPGKLKTNT 918
            .|||:.|.:|:|.||.|||:::   .|...|.|. :.||..:.:...:::..|
  Fly   566 AVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSL-KSSRRGSDMSAIRIRART 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	51/171 (30%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	46/147 (31%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	44/139 (32%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	50/165 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940