Protein Alignment 5-HT2B and Oamb

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 898
• Identity: 194/898 - (21%)
• Similarity: 308/898 - (34%)
• Gaps: 301/898 - (33%)

  Fly    40 NATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRL 104
            |.|...:.:...:|....|....|..|.:.            |||:|   ||.||..|:....:|
  Fly     2 NETECEDLIKSVKWTEPANLISLAVLEFIN------------VLVIG---GNCLVIAAVFCSNKL 51

  Fly   105 QNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISV 169
            ::|||:|:::||:.||:|.:.|:|......|...:..|...|..|:.:||..|||||::||.||:
  Fly    52 RSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISL 116

  Fly   170 DRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKL 234
            |||:::..|:.:....:.::....|..:|:||..:..| .|:..|:..:|:        .|.|
  Fly   117 DRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP-PLVGWKDQKAVI--------QPTY-- 170

  Fly   235 VGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRL 299
                     |.|...|.|  |..:.:.:...||   ..:....|.||
  Fly   171 ---------PKGNHTLYY--TTTMSSSEDGQLG---LDSIKDQGEAS------------------ 203

  Fly   300 LKPGP---GNASSVLHAHSANSTDTDLSTLD-NHELWLP--DSSIKEPTPTTMTALHQFGAEMLK 358
            |.|.|   ||.::.      |..|...:.:| :.|:.:.  ||:....|.||.|
  Fly   204 LPPSPPHIGNGNAY------NPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTT----------- 251

  Fly   359 LSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASP 423
                  :.:|||||  .|:.:..|.|                                    |.|
  Fly   252 ------TASSSSTT--ETEMDLDLLN------------------------------------APP 272

  Fly   424 KGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAV-PGR 487
            :.| ..|:.|  :.....|..:.|..:..|.:|..... ....|....|.|:...|.:.|: .|.
  Fly   273 QNR-PQTISG--SCPWKCELTNDRGYVLYSALGSFYIP-MFVMLFFYWRIYRAAVRTTRAINQGF 333

  Fly   488 EKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKS 552
            :...|.:......|....|||.|:...|..:::::...:|                    |.|
  Fly   334 KTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGST--------------------QST-- 376

  Fly   553 KICHSDTELDPPQKAKQCHIAGQN-HQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRV 616
                 .|.|..|...:....|.:. |..|                         ::||
  Fly   377 -----TTTLGTPSPERLSKYATRRLHHHD-------------------------KIKI------- 404

  Fly   617 TTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSL-T 680
               :.:..||.:..||                         |....||     |.....|::| .
  Fly   405 ---SVSYPSSENISEL-------------------------AGHGDVG-----HERRQSGNALFA 436

  Fly   681 VQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLL-----TPTKTA 740
            |..:|:.          ||     ..|.|.:.....:|        ||.:|..|     .|....
  Fly   437 VHYNGTN----------GR-----ESTESQLYRQQQQH--------GVASSCYLQVGKGLPELAR 478

  Fly   741 TTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSR--NSSVISRN 803
            ..||:|                     |.||                   |.|||  |..:..||
  Fly   479 RQSNTS---------------------EAGG-------------------SGHSRPANKKMGRRN 503

  Fly   804 SSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASS 868
            .....:..|:|.||.|.|.::...|:..|.|||.:.::...|.:|.:.:   :|.|:.||||.:|
  Fly   504 IKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPL---LFSVLFWLGYCNS 565

  Fly   869 MVNPIFYTIFNKVFRQAFKKVL---LCRYSSTSAWRPSRXQTPVKPGKLKTNT 918
            .|||:.|.:|:|.||.|||:::   .|...|.|. :.||..:.:...:::..|
  Fly   566 AVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSL-KSSRRGSDMSAIRIRART 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	55/192 (29%)
		TM helix 1	75..101	CDD:320433	9/25 (36%)
		TM helix 2	108..134	CDD:320433	10/25 (40%)
		TM helix 3	146..176	CDD:320433	16/29 (55%)
		TM helix 4	188..211	CDD:320433	5/22 (23%)
		TM helix 5	229..258	CDD:320433	7/28 (25%)
		7tm_GPCRs	<799..893	CDD:475119	33/96 (34%)
		TM helix 6	818..840	CDD:410628	7/21 (33%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	181/842 (21%)
		TM helix 1	22..48	CDD:320191	11/40 (28%)
		TM helix 2	55..81	CDD:320191	10/25 (40%)
		TM helix 3	93..123	CDD:320191	16/29 (55%)
		TM helix 4	135..158	CDD:320191	6/23 (26%)
		TM helix 5	292..321	CDD:320191	6/29 (21%)
		TM helix 6	512..542	CDD:320191	11/29 (38%)
		TM helix 7	551..576	CDD:320191	11/27 (41%)