Protein Alignment 5-HT2B and 5-HT7

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 824
• Identity: 157/824 - (19%)
• Similarity: 226/824 - (27%)
• Gaps: 465/824 - (56%)

  Fly    77 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPL 141
            :::.|:::|||..||:|||:|:...|:|:...||.|:|||::||.||:||||:.:|..|...:..
  Fly   166 SIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCVALLVMPMALLYEVLEKWNF 230

  Fly   142 GSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL 206
            |...|..|:..|||.|||||::||.|||||||::..|:.:|..:|.||:.|.:..|||.:..:||
  Fly   231 GPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRTPRRMMLCVGIVWLAAACISL 295

  Fly   207 PLSLMYSKNHASVLVNGTCQI-PDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQ 270
            |..|:....|........|.: .:..|::..::..|||||.|||..|....|
  Fly   296 PPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLFVYYQIFR------------- 347

  Fly   271 QTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPD 335
               ||                     ||:          ||....|
  Fly   348 ---AA---------------------RRI----------VLEEKRA------------------- 359

  Fly   336 SSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAAT 400
                      .|.|.|                :.:.|||                ||:|
  Fly   360 ----------QTHLQQ----------------ALNGTGS----------------PSAP------ 376

  Fly   401 HQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLS 465
                               ||.|.|                     ...||||..|
  Fly   377 -------------------QAPPLG---------------------HTELASSGNG--------- 392

  Fly   466 QLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQE 530
                                                         :||:|:
  Fly   393 ---------------------------------------------QRHSSV-------------- 398

  Fly   531 SLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595
                                                                             
  Fly   399 ----------------------------------------------------------------- 398

  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660
                                                      || .|||.|...|::.|
  Fly   399 ------------------------------------------GN-TSLTYSTCGGLSSG------ 414

  Fly   661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725
               |..|:.|              |||
  Fly   415 ---GGALAGH--------------GSG-------------------------------------- 424

  Fly   726 GGV--RTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQT 788
            |||  .|.||.:|                    .|:.:.:|
  Fly   425 GGVSGSTGLLGSP--------------------HHKKLRFQ------------------------ 445

  Fly   789 VRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLL-PTVCAECEERI 852
                                  :..|:||:..||::...|.:.|.|||:|.|: |.........:
  Fly   446 ----------------------LAKEKKASTTLGIIMSAFTVCWLPFFILALIRPFETMHVPASL 488

  Fly   853 SHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS 896
            |    .:..|||||:|::|||.|...|:.||:.|:::|..|.||
  Fly   489 S----SLFLWLGYANSLLNPIIYATLNRDFRKPFQEILYFRCSS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	74/190 (39%)
		TM helix 1	75..101	CDD:320433	10/23 (43%)
		TM helix 2	108..134	CDD:320433	15/25 (60%)
		TM helix 3	146..176	CDD:320433	19/29 (66%)
		TM helix 4	188..211	CDD:320433	9/22 (41%)
		TM helix 5	229..258	CDD:320433	10/28 (36%)
		7tm_GPCRs	<799..893	CDD:475119	29/94 (31%)
		TM helix 6	818..840	CDD:410628	8/21 (38%)
		TM helix 7	854..879	CDD:410628	10/24 (42%)
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	152/812 (19%)
		TM helix 1	164..190	CDD:320452	10/23 (43%)
		TM helix 2	197..223	CDD:320452	15/25 (60%)
		TM helix 3	235..265	CDD:320452	19/29 (66%)
		TM helix 4	277..299	CDD:320452	9/21 (43%)
		TM helix 5	319..348	CDD:320452	11/44 (25%)
		TM helix 6	447..477	CDD:320452	12/29 (41%)
		TM helix 7	486..511	CDD:320452	11/28 (39%)