Protein Alignment 5-HT2B and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 942
• Identity: 232/942 - (24%)
• Similarity: 336/942 - (35%)
• Gaps: 320/942 - (33%)

  Fly     9 LGAYNDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQL---HVARWNATGNAT---------I 61
            |||..|.   .||......|.|.|.......|.|:....:   ::...|.|..|:         :
  Fly   212 LGAERDG---LWSFLNLSELMEPDHGFLGIMNVTNTSLDMFLPNLTALNTTSTASTADMATEFAV 273

  Fly    62 SATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLV 126
            :.:|.|......::..|..:..:.....||||||||:|.:|:|||||||||.||||.||:|::.|
  Fly   274 TKSFLDYSPHGYDFLFLFVVFFIFAGGLGNILVCLAVALDRKLQNVTNYFLFSLAIADLLVSLFV 338

  Fly   127 MPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVT 191
            ||:|.:....||:|||...|..::..|||.|::||:|:|.||:.||:.:|.|:......|:|...
  Fly   339 MPMGAIPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRNPLGSRHRSTKRLTG 403

  Fly   192 LKIVFVWLLSIAMSLPLSLMYSKNHASVLVN-GTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLT 255
            :||..||::::.:|..::::...|..:::.. ..|.|.:..:.:.||:|.||||:.:|:.||.||
  Fly   404 IKIAIVWVMAMMVSSSITVLGLVNEKNIMPEPNICVINNRAFFVFGSLVAFYIPMLMMVTTYALT 468

  Fly   256 VRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTD 320
            :.||.::       .:.||..|         ...|.||...|..|:|          .||...
  Fly   469 IPLLRKK-------ARFAAEHP---------ESELFRRLGGRFTLRP----------QHSQQQ-- 505

  Fly   321 TDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNH 385
                                        |..|                         |.||.||:
  Fly   506 ----------------------------LQMF-------------------------SSFSGSNN 517

  Fly   386 LQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSL 450
            ..|.....              |...:..|...:..:|..|.|.              |.....|
  Fly   518 KFLSMGDG--------------NRNFNTEGEMEEGGAPSRRSGV--------------EPAERPL 554

  Fly   451 ASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNS 515
            ...|....:|.||:|        ::.....:|...|..:|.            |.|     .|:|
  Fly   555 MQQRTASSRSMGTVS--------FRNVVNGTSGAAGSGRRT------------TGT-----AHSS 594

  Fly   516 LP-KNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQS 579
            .. ..|...||::                                    ...|..||....:..|
  Fly   595 FRFSGAGIFRHSS------------------------------------SSPASSCHSTSTSRSS 623

  Fly   580 DYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644
            .:.:...  ..|...||               .|..:..:....||.|:          .:.|:.
  Fly   624 SFWRKHG--GYPNLMDR---------------LAIHLRLSLVPPSSHPN----------RRASVR 661

  Fly   645 SSVSAGITGGP---AGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISK 706
            .::|....|.|   .|....|||:|             .|.:.|:|
  Fly   662 VTISQPQLGYPTNVGGNGGRTVGAT-------------EVGAGGNG------------------- 694

  Fly   707 TASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGG 771
                    ||..|...||.||  |||:...|......|.|                 |.||  |.
  Fly   695 --------SSAGRTSNSSLGG--TSLMKIATIQGPILNQS-----------------QAAG--GN 730

  Fly   772 ----KTRTTTSSPCMLQRQQT-------------------VRSHHSRNSSVISRNSSRHGRIIRL 813
                |.:.|...|...||.:.                   :.:...|||  :|.|:      :..
  Fly   731 HMVQKVKPTALKPEEPQRNKVRPFKFAFNRVATPTLNLRFLNNRSKRNS--LSANA------VAT 787

  Fly   814 EQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIF 878
            |||||||||:||||||:.|||||:||::...|.||:  :...|.:...||||.||.:|||.||||
  Fly   788 EQKATKVLGLVFFTFVLCWSPFFILNIIFAACPECQ--VPEHVVNTCLWLGYVSSTINPIIYTIF 850

  Fly   879 NKVFRQAFKKVLLC---------RYSSTSAWR 901
            |:.||.||.::|.|         ||.|.:..|
  Fly   851 NRTFRAAFIRLLKCNCKRSGRPLRYRSVTEGR 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	75/193 (39%)
		TM helix 1	75..101	CDD:320433	10/25 (40%)
		TM helix 2	108..134	CDD:320433	16/25 (64%)
		TM helix 3	146..176	CDD:320433	13/29 (45%)
		TM helix 4	188..211	CDD:320433	6/22 (27%)
		TM helix 5	229..258	CDD:320433	12/28 (43%)
		7tm_GPCRs	<799..893	CDD:475119	48/102 (47%)
		TM helix 6	818..840	CDD:410628	17/21 (81%)
		TM helix 7	854..879	CDD:410628	13/24 (54%)
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	73/174 (42%)
		TM helix 2	321..343	CDD:410628	14/21 (67%)
		TM helix 3	359..381	CDD:410628	9/21 (43%)
		TM helix 4	404..420	CDD:410628	5/15 (33%)
		TM helix 5	443..466	CDD:410628	9/22 (41%)
		7tm_GPCRs	<779..858	CDD:475119	45/88 (51%)
		TM helix 6	792..814	CDD:410628	17/21 (81%)
		TM helix 7	826..851	CDD:410628	13/24 (54%)