DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT2B and CG13579

DIOPT Version :9

Sequence 1:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	NP_001261169.1	Gene:	CG13579 / 37905	FlyBaseID:	FBgn0035010	Length:	716	Species:	Drosophila melanogaster

Alignment Length:	853	Identity:	171/853 - (20%)
Similarity:	269/853 - (31%)	Gaps:	272/853 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SRHNQL-HVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERR--- 103
            |.||.: |:.         |:.|.|          |:|.|||.||....|.||...|. .||
  Fly    25 SGHNFIAHIG---------IAETIE----------AVLILVLTLGVIGANCLVIFVIN-NRRYAA 69

  Fly   104 -LQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTI 167
             :.....|.|.|||:.||.:.:|:.|.|::..:...:|.|...|.....|.......|.:.|..:
  Fly    70 YIHQQPRYLLTSLALNDLTIGLLITPFGLMPALFHCWPYGEIFCQIQALLRGALSQQSAVILVCM 134

  Fly   168 SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM--SLPLSLMYSKNHASVLVNGTCQ--IP 228
            :||||:...:|.|:.::.:::.....:...|::|:.:  .|.|...|..|:..::   .|:  ..
  Fly   135 AVDRYMCALHPRRYYQHSSKKGCVAILSLTWIISLTVFGFLVLPKGYYFNNTGLM---ACEPFYS 196

  Fly   229 DPVYKLVGSIVCFYIPLGVMLLTYCLTVRL-LARQRQNLGGGQQTAAATPGWASGWLGQAPALER 292
            .|.|::: |....|.|. .|:|.||..... ::|.|.|......||||.
  Fly   197 KPSYRIL-STCALYFPT-TMVLMYCYGSSFHMSRFRLNDPTMPLTAAAH---------------- 243

  Fly   293 RCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEML 357
                    .|.|       |.|                          ||......:||.
  Fly   244 --------HPHP-------HPH--------------------------PTAAQQLQMHQH----- 262

  Fly   358 KLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQAS 422
                            .....:..:.:||.             |..|||.:|..||....| ...
  Fly   263 ----------------QQHHQQAGMHSHLY-------------HGHSHHPSHPSHPNHPNH-HGH 297

  Fly   423 PKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGR 487
            |. .||..|:|             ..|:|.| ||........:::::::            ||.:
  Fly   298 PH-HHGPPVMG-------------HLSMAMS-MGLAGMPNMTNKITKKI------------VPIQ 335

  Fly   488 EKRAGHEDA-------------------DEDVETPTSTLRRHKRHNSLP------------KNAL 521
            ||.:....:                   .|.|...|.        :.||            .|:|
  Fly   336 EKNSSGSTSRSMAAISLGFIVMVTPWTIQEIVTACTG--------SKLPPFLDFLVTWTALSNSL 392

  Fly   522 YPRHTTVQESLDDDDDEEEESAQQKDQQTKSKIC--HSDTELDPPQKAKQCHIAGQNHQSDYLQL 584
            :  :..:...|:.|       .::..:|.....|  |.||   |..|:..|||    :.:|:
  Fly   393 W--NPFMYWLLNSD-------FRRMSRQLMPNKCFPHEDT---PEHKSGCCHI----NANDF--- 438

  Fly   585 PSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSA 649
             .:.|.|...:.|.......|.......:....::...|:||.....|.:|......||:.|.|.
  Fly   439 -EITTLPIPPEPPSSRPPGGAGGGGGGPSSGGPSSGGGVASSIGGSVLGICGRSRTNSLSRSASQ 502

  Fly   650 GITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDG---------------SGYLAA------PG 693
            .|.|        |:|..:..|.|....|:.....:|               ||.|.|      |.
  Fly   503 YIRG--------TMGGGVHNHQATETFSTTRPDIEGLSEKYWGEILERTVSSGNLNAMQKHLPPH 559

  Fly   694 TPCPGRRKLSISKTASVVTWDSSRHRRRGSSF---GGVRTSLLLTPTKTATT----SNSSTPLRR 751
            .|........|.:       ....|:::.:||   ..::.:|.|:...||..    |||...|..
  Fly   560 LPYAHHLVHQIHQ-------PQQHHQQQTTSFSKASDLQLNLNLSQAATAAELGKFSNSEPKLCE 617

  Fly   752 SA--TLRSHQNMNYQGAGECGGKTRTTTSSPCM------------LQRQQTVRSHHSRNSSVISR 802
            ..  .:...::....|.||..||.....|.|.:            |..:|...|||..:....:|
  Fly   618 HLFHDVNCAKSKAANGDGESSGKLACGRSIPDIXYAEDVILAKNQLLARQAKCSHHPLHQQAKTR 682

  Fly   803 NSSRHGRI 810
            ..|..|.:
  Fly   683 LHSHTGSL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	44/180 (24%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	37/155 (24%)
CG13579	NP_001261169.1	7tm_4	51..>148	CDD:304433	27/97 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930