Protein Alignment 5-HT2B and mAChR-A

DIOPT Version :9

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 200/946 - (21%)
• Similarity: 336/946 - (35%)
• Gaps: 304/946 - (32%)

  Fly    35 QRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLG---------TAAG 90
            :..|:.|.|.....:...:....|.||.       |:.......||.::|:|         |.||
  Fly    64 ENLTSTAASGLYDPYSGMYGNQTNGTIG-------FETKGPRYSLASMVVMGFVAAILSTVTVAG 121

  Fly    91 NILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVL 155
            |::|.::...:::||.::||||.||||.|..:..:.|||..:|.:.||:|||...|.||:.||.|
  Fly   122 NVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYL 186

  Fly   156 FCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVL 220
            ...||:::|..||.|||.|:..|:.:...:|..|..:.|...|.:|:.:..|  .:||..:
  Fly   187 ASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGISLLLWPP--WIYSWPY---- 245

  Fly   221 VNGTCQIP-DPVY----------KLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAA 274
            :.|...:| |..|          ....::..||.|:.:|...|....|...:::::|
  Fly   246 IEGKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDL-------- 302

  Fly   275 ATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIK 339
                         |.|:            .|...|     |..|..:|.:|:.||
  Fly   303 -------------PNLQ------------AGKKDS-----SKRSNSSDENTVVNH---------- 327

  Fly   340 EPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQ-Q 403
              ....:.|..|.|             .:...|....:||.|         |.:...|..... .
  Fly   328 --ASGGLLAFAQVG-------------GNDHDTWRRPRSESS---------PDAESVYMTNMVID 368

  Fly   404 SHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLS 468
            |.:|       |::.:::|.|   .|..:..|.|..|..:|.   .:|....|.|.||..
  Fly   369 SGYH-------GMHSRKSSIK---STNTIKKSYTCFGSIKEW---CIAWWHSGREDSDDF----- 415

  Fly   469 QRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLD 533
                ||::                .|.:|....||.:.        ..|..:...|.|::....|
  Fly   416 ----AYEQ----------------EEPSDLGYATPVTI--------ETPLQSSVSRCTSMNVMRD 452

  Fly   534 DDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPL 598
            :                 ..:..|.:.:.||.                :.|..|...|.  .||
  Fly   453 N-----------------YSMGGSVSGVRPPS----------------ILLSDVSPTPL--PRP- 481

  Fly   599 QNCVKSAEVKIISSAFRVTTTTTA-VSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPAT 662
                ..|.:..:.....||.:||| |::|         .:||
  Fly   482 ----PLASISQLQEMSAVTASTTANVNTS---------GNGN----------------------- 510

  Fly   663 VGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGG 727
             |:..:.::|.:.|:. .|..:|:|..:..|....|......|:|..|:    :|...|..|...
  Fly   511 -GAINNNNNASHNGNG-AVNGNGAGNGSGIGLGTTGNATHRDSRTLPVI----NRINSRSVSQDS 569

  Fly   728 VRTSLLLTPTKTATTSNSST-----PLRRSATLRSHQNMNYQGAGECG---------GKTRTTTS 778
            |.|.|:..|:..| :||::.     |   .|...:..:::.|  |:|.         |.|.|..:
  Fly   570 VYTILIRLPSDGA-SSNAANGGGGGP---GAGAAASASLSMQ--GDCAPSIKMIHEDGPTTTAAA 628

  Fly   779 SPCM-------------------LQRQQTVRSHHSR--NSSVI---------------------- 800
            :|..                   |.|:.:...|.:|  |:.||
  Fly   629 APLASAAATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHAL 693

  Fly   801 --SRNSS---RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLP--TVCAECEERISHWVFD 858
              :||::   :..:..|.|.||.|.|..:..:|:|.|:|:.:|.|:.  |.|::|   |...::|
  Fly   694 MNARNAAKKKKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDC---IPTELWD 755

  Fly   859 VVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRY 894
            ....|.|.:|.:||:.|.:.|..||:.:.::|.|::
  Fly   756 FFYALCYINSTINPMCYALCNATFRRTYVRILTCKW 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	57/182 (31%)
		7tm_4	90..>238	CDD:304433	51/158 (32%)
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	47/125 (38%)
		7tm_1	121..>314	CDD:278431	62/236 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940