Protein Alignment 5-HT2B and drd2l

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_068070012.2
• Gene: drd2l / 378718
• ZFINID: ZDB-GENE-030910-1
• Length: 450
• Species: Danio rerio
• Alignment Length: 875
• Identity: 166/875 - (18%)
• Similarity: 255/875 - (29%)
• Gaps: 449/875 - (51%)

  Fly    27 VLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGN 91
            ||...:|...|.:.:::....||      ..|.::|.:....|:   |::|:|.::|:.....||
Zfish    16 VLNVTEELTITASPSSAVFLSLH------QSNCSVSPSPSSPPY---NFYAVLLVLLIFCVVFGN 71

  Fly    92 ILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLF 156
            :|||:|::.|:.||..|||.::|||::||::|.||||.|:...|.|.:.....||...:.|||:.
Zfish    72 VLVCVAVSREKALQTTTNYLIVSLAVSDLLLATLVMPWGVYLEVVGEWRFSRIHCDVLLTLDVMM 136

  Fly   157 CTASIMHLCTISVDRYLSLRYPMRFG-RNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVL 220
            |||||::||.||:|||.::..|:.:. |..:||||.|.|..||.||.|:|.|  |::..|:.:..
Zfish   137 CTASILNLCAISIDRYTAVAMPLLYNTRYSSRRRVALMIAVVWFLSFAISCP--LLFGLNNTASQ 199

  Fly   221 VNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLG 285
            ....|...||.:.:..|:..||:|..|.||.| :.:.::.|:|     |::||
Zfish   200 EGRDCSFADPAFVVYSSVASFYVPFIVTLLVY-VQICVVLRRR-----GRRTA------------ 246

  Fly   286 QAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALH 350
                                                                             
Zfish   247 ----------------------------------------------------------------- 246

  Fly   351 QFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAG 415
                                    ||
Zfish   247 ------------------------PT--------------------------------------- 248

  Fly   416 VYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRA 480
                                                                         ||||
Zfish   249 -------------------------------------------------------------RRRA 252

  Fly   481 SSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQ 545
            ::..|...:|:
Zfish   253 ANTEPADAQRS------------------------------------------------------ 263

  Fly   546 KDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKII 610
                .|:|..|       |:..|.|.:
Zfish   264 ----RKNKCTH-------PEDVKLCTL-------------------------------------- 279

  Fly   611 SSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQ 675
                                                    |...||.|
Zfish   280 ----------------------------------------ILKPPAAA----------------- 287

  Fly   676 GSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTA--------SVVTWDSSRHRRRGSSFGGVRTSL 732
                                 |.|:|:::.|.|        .|.:..:.|.:.:....|..:.||
Zfish   288 ---------------------PQRKKVTLVKEAVVHPLAVEPVCSLSADREQTQTQPSGRAKLSL 331

  Fly   733 LLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNS 797
            .:.|.                            ||:.|...|..|     ||.:.....|.:...
Zfish   332 SVAPC----------------------------AGQSGPGPRRDT-----LQEKTHTEKHAAAKE 363

  Fly   798 SVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTW 862
            .|..|.|.:.      |:|||::|.:|...|:|.|.|||:.::|...|..|  .||..::..|||
Zfish   364 RVRGRLSQQK------ERKATQMLAIVLGVFIICWLPFFLTHVLKAHCGSC--CISPSLYSAVTW 420

  Fly   863 LGYASSMVNPIFYTIFNKVFRQAFKKVLLC 892
            |||.:|.|||:.||.||..||:||.|:|.|
Zfish   421 LGYLNSAVNPVIYTTFNIEFRKAFIKILHC 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	76/193 (39%)
		TM helix 1	75..101	CDD:320433	9/25 (36%)
		TM helix 2	108..134	CDD:320433	14/25 (56%)
		TM helix 3	146..176	CDD:320433	16/29 (55%)
		TM helix 4	188..211	CDD:320433	12/22 (55%)
		TM helix 5	229..258	CDD:320433	10/28 (36%)
		7tm_GPCRs	<799..893	CDD:475119	41/94 (44%)
		TM helix 6	818..840	CDD:410628	9/21 (43%)
		TM helix 7	854..879	CDD:410628	12/24 (50%)
drd2l	XP_068070012.2	None