Protein Alignment 5-HT2B and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 888
• Identity: 201/888 - (22%)
• Similarity: 291/888 - (32%)
• Gaps: 348/888 - (39%)

  Fly    37 TTANATSRHNQLHVARWNAT--GNATISATFEDVPFD----ANNYWAL---LALVLVLG-----T 87
            ||:|       |....||.:  ||.. |.||:.|..:    |..:|.|   :|:.:|||     |
  Fly    48 TTSN-------LSQIVWNRSINGNGN-SNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVT 104

  Fly    88 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICL 152
            ..||:.|..||..||.||||.||.:.|||:.||.||.||||||.:..:...:.||.|.|..|...
  Fly   105 IIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNGWILGPELCDIWTSC 169

  Fly   153 DVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKNH 216
            |||.|||||:||..|:.|||.::. .:.:...:|.|||.|.|..||..::.:|| |.......::
  Fly   170 DVLCCTASILHLVAIAADRYWTVT-NIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWKDPDY 233

  Fly   217 ASVLVNGTCQIPDPV-YKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWA 280
            ...:....|.:...| |::..:...||:||.|:|..| ..:.::||:|
  Fly   234 MKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLY-WKIYIIARKR----------------- 280

  Fly   281 SGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTT 345
                     ::||..                .:.:...|:||.           ||:::|
  Fly   281 ---------IQRRAQ----------------KSFNVTLTETDC-----------DSAVRE----- 304

  Fly   346 MTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQ 410
                       ||..|.
  Fly   305 -----------LKKERS------------------------------------------------ 310

  Fly   411 QHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLR--- 472
                                           :|.:.|..|.:........|||..||.:|.|
  Fly   311 -------------------------------KRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRM 344

  Fly   473 --AYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLP----KNALYPRHTTVQES 531
              .:.:....::.|.|.|.......|...|:..:..:.|.:...|..    |:......|||...
  Fly   345 RICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSD 409

  Fly   532 LDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDR 596
            .||.............||    :.|          |.|.|:...:
  Fly   410 ADDYRTSNANEIITLSQQ----VAH----------ATQHHLIASH-------------------- 440

  Fly   597 PLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPA 661
              .|.:......|........||||     |||..|    ||     ..:|:..:.||
  Fly   441 --LNAITPLAQSIAMGGVGCLTTTT-----PSEKAL----SG-----AGTVAGAVAGG------- 482

  Fly   662 TVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFG 726
                         .||       |||...| ||                      ..:..|...|
  Fly   483 -------------SGS-------GSGEEGA-GT----------------------EGKNAGVGLG 504

  Fly   727 GVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRS 791
            ||..|:             :.|         ||.                     :.:|:|.:.:
  Fly   505 GVLASI-------------ANP---------HQK---------------------LAKRRQLLEA 526

  Fly   792 HHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWV 856
                                :.|:||.:.|.::...|||.|.||||:.|..::|.|||  |...|
  Fly   527 --------------------KRERKAAQTLAIITGAFVICWLPFFVMALTMSLCKECE--IHTAV 569

  Fly   857 FDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSA 899
            ..:..||||.:|.:||:.|||||..||:|||::|..|.::..|
  Fly   570 ASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRILFGRKAAARA 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	67/173 (39%)
		7tm_4	90..>238	CDD:304433	59/149 (40%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	71/224 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010