DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and HTR7

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_062873.1 Gene:HTR7 / 3363 HGNCID:5302 Length:479 Species:Homo sapiens


Alignment Length:526 Identity:127/526 - (24%)
Similarity:189/526 - (35%) Gaps:196/526 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DVYASLGAY-------------NDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNA 55
            |:|..|.::             .|.|.|..:.|     |........||:.        ...|:|
Human    11 DLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGS-----WAPHLLSEVTASP--------APTWDA 62

  Fly    56 -TGNATISATFEDVPFDANNY--------WALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYF 111
             ..||  |...|.:     ||        .::|.|:.:| |.|||.||.:::.:.::|:..:||.
Human    63 PPDNA--SGCGEQI-----NYGRVEKVVIGSILTLITLL-TIAGNCLVVISVCFVKKLRQPSNYL 119

  Fly   112 LMSLAITDLMVAVLVMP-LGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSL 175
            ::|||:.||.|||.||| :.:..|:.|.:..|...|..:|.:||:.||||||.||.||:||||.:
Human   120 IVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184

  Fly   176 RYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNG--TCQI-PDPVYKLVGS 237
            ..|:.:...:..:.:...|:.|||||.:::||....:::|     ||.  .|.| .|..|.:..:
Human   185 TRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQN-----VNDDKVCLISQDFGYTIYST 244

  Fly   238 IVCFYIPLGVMLLTY------------------------------------------CLTV-RLL 259
            .|.||||:.|||..|                                          |..: |||
Human   245 AVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLL 309

  Fly   260 ARQRQNLG--GGQQTAAATPGWASG------------------------------------WLGQ 286
            ..:|:|:.  ..:|.||.|.|...|                                    |||.
Human   310 KHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGY 374

  Fly   287 APAL-----------ERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKE 340
            |.:|           :.|.|:|.||:....|.:..|.|                           
Human   375 ANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSA--------------------------- 412

  Fly   341 PTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSL---SNHLQLQYPSSPQRYAATHQ 402
                  ..:|    |.|||:.            .|.:.||.|   :..:.|:....|.......|
Human   413 ------AGMH----EALKLAE------------RPERPEFVLRACTRRVLLRPEKRPPVSVWVLQ 455

  Fly   403 QSHHHN 408
            ...|||
Human   456 SPDHHN 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 77/247 (31%)
TM helix 1 75..101 CDD:320433 10/33 (30%)
TM helix 2 108..134 CDD:320433 13/26 (50%)
TM helix 3 146..176 CDD:320433 18/29 (62%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 12/71 (17%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
HTR7NP_062873.1 7tmA_5-HT7 97..395 CDD:320452 83/302 (27%)
TM helix 2 116..142 CDD:320452 13/25 (52%)
TM helix 3 155..185 CDD:320452 18/29 (62%)
TM helix 4 197..219 CDD:320452 8/21 (38%)
TM helix 5 236..265 CDD:320452 11/28 (39%)
TM helix 6 320..350 CDD:320452 6/29 (21%)
TM helix 7 363..388 CDD:320452 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

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