DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and HTR1F

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000857.1 Gene:HTR1F / 3355 HGNCID:5292 Length:366 Species:Homo sapiens


Alignment Length:816 Identity:131/816 - (16%)
Similarity:206/816 - (25%) Gaps:488/816 - (59%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCL 147
            |.|.|...|.||..||...|:|.:..||.:.|||:||.:|||||||..|:.:|:..:.:|...|.
Human    33 LALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCD 97

  Fly   148 TWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMY 212
            .|:.:|:..||.||:||..|::|||.::...:.:.|.:|.:...:.|..||::|:.:|:| .|.:
Human    98 IWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMP-PLFW 161

  Fly   213 SKNHASVLVNGTC-----QIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQT 272
              .|.....:..|     .|...:|...|:   |||||.::|:.|....|               
Human   162 --RHQGTSRDDECIIKHDHIVSTIYSTFGA---FYIPLALILILYYKIYR--------------- 206

  Fly   273 AAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSS 337
            ||.|                                                             
Human   207 AAKT------------------------------------------------------------- 210

  Fly   338 IKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQ 402
                                                                             
Human   211 ----------------------------------------------------------------- 210

  Fly   403 QSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQL 467
                         :||::                              .:||:..|:.:|.:   
Human   211 -------------LYHKR------------------------------QASRIAKEEVNGQV--- 229

  Fly   468 SQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESL 532
              .|.:.:|..::.|                     ||.:                    :::||
Human   230 --LLESGEKSTKSVS---------------------TSYV--------------------LEKSL 251

  Fly   533 DDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRP 597
            .|                      ..|:.|                                   
Human   252 SD----------------------PSTDFD----------------------------------- 259

  Fly   598 LQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPAT 662
                      ||.|:          |.|..||.:       ::||                    
Human   260 ----------KIHST----------VRSLRSEFK-------HEKS-------------------- 277

  Fly   663 VGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGG 727
                                                              |       |.....|
Human   278 --------------------------------------------------W-------RRQKISG 285

  Fly   728 VRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSH 792
            .|                                                               
Human   286 TR--------------------------------------------------------------- 287

  Fly   793 HSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVF 857
                                 |:||...||::...|||.|.||||..|:..||.:|  :||..:.
Human   288 ---------------------ERKAATTLGLILGAFVICWLPFFVKELVVNVCDKC--KISEEMS 329

  Fly   858 DVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
            :.:.||||.:|::||:.|||||:.|::||:|::.||
Human   330 NFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 62/188 (33%)
TM helix 1 75..101 CDD:320433 8/17 (47%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 13/29 (45%)
TM helix 4 188..211 CDD:320433 6/22 (27%)
TM helix 5 229..258 CDD:320433 9/28 (32%)
7tm_GPCRs <799..893 CDD:475119 35/93 (38%)
TM helix 6 818..840 CDD:410628 10/21 (48%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
HTR1FNP_000857.1 7tmA_5-HT1F 24..359 CDD:320456 127/808 (16%)
TM helix 1 25..51 CDD:320456 8/17 (47%)
TM helix 2 58..84 CDD:320456 15/25 (60%)
TM helix 3 96..126 CDD:320456 13/29 (45%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 120..122 1/1 (100%)
TM helix 4 138..160 CDD:320456 6/22 (27%)
TM helix 5 178..207 CDD:320456 11/46 (24%)
TM helix 6 286..316 CDD:320456 15/113 (13%)
TM helix 7 326..351 CDD:320456 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 343..347 2/3 (67%)

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