Protein Alignment 5-HT2B and HTR1D

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_000855.1
• Gene: HTR1D / 3352
• HGNCID: 5289
• Length: 377
• Species: Homo sapiens
• Alignment Length: 854
• Identity: 139/854 - (16%)
• Similarity: 214/854 - (25%)
• Gaps: 508/854 - (59%)

  Fly    58 NATISATFEDVPFDANNYWAL---LALVL---VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLA 116
            |.:::||.....:|.....||   ||:||   .|.|...|..|...|...|:|....||.:.|||
Human    17 NRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLA 81

  Fly   117 ITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF 181
            .|||:|::||||:.|...:...:..|...|..|:..|:..|||||:|||.|::|||.::...:.:
Human    82 TTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEY 146

  Fly   182 GRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHA-----SVLVNGTCQIPDPVYKLVGSIVCF 241
            .:.:|.......|..||.:||.:|:| .|.:.:..|     ..||| |.||...:|...|:   |
Human   147 SKRRTAGHAATMIAIVWAISICISIP-PLFWRQAKAQEEMSDCLVN-TSQISYTIYSTCGA---F 206

  Fly   242 YIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGN 306
            |||..::::.|
Human   207 YIPSVLLIILY------------------------------------------------------ 217

  Fly   307 ASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSST 371
                                                                             
Human   218 ----------------------------------------------------------------- 217

  Fly   372 TGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLST 436
                                                                             
Human   218 ----------------------------------------------------------------- 217

  Fly   437 TTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVE 501
                                                             ||..||
Human   218 -------------------------------------------------GRIYRA---------- 223

  Fly   502 TPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQK 566
                                                            .:::|      |:||.
Human   224 ------------------------------------------------ARNRI------LNPPS- 233

  Fly   567 AKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEME 631
                                     .:|.|             .::|..:|
Human   234 -------------------------LYGKR-------------FTTAHLIT-------------- 246

  Fly   632 LLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPC 696
                                  |.||::..::.|:|....:|:.||.|
Human   247 ----------------------GSAGSSLCSLNSSLHEGHSHSAGSPL----------------- 272

  Fly   697 PGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNM 761
                                       .|..|:..|          ::|:...:|.:..|
Human   273 ---------------------------FFNHVKIKL----------ADSALERKRISAAR----- 295

  Fly   762 NYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFF 826
                                                                |:||||:||::..
Human   296 ----------------------------------------------------ERKATKILGIILG 308

  Fly   827 TFVILWSPFFVLNLLPTVCAECEERISHWV----FDVVTWLGYASSMVNPIFYTIFNKVFRQAFK 887
            .|:|.|.||||::|:..:|     |.|.|:    ||..|||||.:|::|||.||:||:.|||||:
Human   309 AFIICWLPFFVVSLVLPIC-----RDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQ 368

  Fly   888 KVLLCRYSS 896
            |::..|.:|
Human   369 KIVPFRKAS 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	66/203 (33%)
		TM helix 1	75..101	CDD:320433	11/31 (35%)
		TM helix 2	108..134	CDD:320433	14/25 (56%)
		TM helix 3	146..176	CDD:320433	15/29 (52%)
		TM helix 4	188..211	CDD:320433	7/22 (32%)
		TM helix 5	229..258	CDD:320433	7/28 (25%)
		7tm_GPCRs	<799..893	CDD:475119	40/97 (41%)
		TM helix 6	818..840	CDD:410628	11/21 (52%)
		TM helix 7	854..879	CDD:410628	14/28 (50%)
HTR1D	NP_000855.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		1/5 (20%)
		7tmA_5-HT1B_1D	35..367	CDD:320455	130/824 (16%)
		TM helix 1	40..66	CDD:320455	9/25 (36%)
		TM helix 2	73..99	CDD:320455	14/25 (56%)
		TM helix 3	111..141	CDD:320455	15/29 (52%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	135..137		1/1 (100%)
		TM helix 4	153..176	CDD:320455	8/23 (35%)
		TM helix 5	194..223	CDD:320455	11/264 (4%)
		TM helix 6	294..324	CDD:320455	16/86 (19%)
		TM helix 7	335..360	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	352..356		3/3 (100%)