DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and HTR1A

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000515.2 Gene:HTR1A / 3350 HGNCID:5286 Length:422 Species:Homo sapiens


Alignment Length:855 Identity:151/855 - (17%)
Similarity:235/855 - (27%) Gaps:473/855 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 NATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAIT 118
            |.||.:.::.:::.:.       :||...|:.....||..|..|||.||.||||.||.:.|||:|
Human    24 NTTGISDVTVSYQVIT-------SLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVT 81

  Fly   119 DLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGR 183
            ||||:|||:|:..|..|...:.||...|..:|.||||.||:||:|||.|::|||.::..|:.:..
Human    82 DLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 146

  Fly   184 NKTRRRVTLKIVFVWLLSIAMSLPLSLMY--------------SKNHASVLVNGTCQIPDPVYKL 234
            .:|.||....|...||:...:|:|..|.:              ||:|.              |.:
Human   147 KRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHG--------------YTI 197

  Fly   235 VGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRL 299
            ..:...|||||.:||:.|                             |.:.:|.....|.|.:::
Human   198 YSTFGAFYIPLLLMLVLY-----------------------------GRIFRAARFRIRKTVKKV 233

  Fly   300 LKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLE 364
            .|.|               .||                             :.||          
Human   234 EKTG---------------ADT-----------------------------RHGA---------- 244

  Fly   365 SVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGT 429
                     ||                 :||...:.:.:|...|.:                   
Human   245 ---------SP-----------------APQPKKSVNGESGSRNWR------------------- 264

  Fly   430 TVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHE 494
                     ||:|          |:.||...                   |:.||     |.|.:
Human   265 ---------LGVE----------SKAGGALC-------------------ANGAV-----RQGDD 286

  Fly   495 DADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDT 559
            .|..:|      :..|:..||                                            
Human   287 GAALEV------IEVHRVGNS-------------------------------------------- 301

  Fly   560 ELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVS 624
                               .::|.|||                                      
Human   302 -------------------KEHLPLPS-------------------------------------- 309

  Fly   625 SSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYL 689
                                       ..||                                  
Human   310 ---------------------------EAGP---------------------------------- 313

  Fly   690 AAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSAT 754
                |||                                                          
Human   314 ----TPC---------------------------------------------------------- 316

  Fly   755 LRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATK 819
                                    :|...:|:.. |:..::....::|           |:|..|
Human   317 ------------------------APASFERKNE-RNAEAKRKMALAR-----------ERKTVK 345

  Fly   820 VLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQ 884
            .||::..||::.|.|||::.|:...| |....:...:..::.||||::|::||:.|..|||.|:.
Human   346 TLGIIMGTFILCWLPFFIVALVLPFC-ESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQN 409

  Fly   885 AFKKVLLCRY 894
            ||||::.|::
Human   410 AFKKIIKCKF 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 72/206 (35%)
TM helix 1 75..101 CDD:320433 9/25 (36%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 17/29 (59%)
TM helix 4 188..211 CDD:320433 7/22 (32%)
TM helix 5 229..258 CDD:320433 9/28 (32%)
7tm_GPCRs <799..893 CDD:475119 31/93 (33%)
TM helix 6 818..840 CDD:410628 9/21 (43%)
TM helix 7 854..879 CDD:410628 8/24 (33%)
HTR1ANP_000515.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
7tmA_5-HT1A_vertebrates 37..411 CDD:320453 143/832 (17%)
TM helix 1 38..64 CDD:320453 9/32 (28%)
TM helix 2 71..97 CDD:320453 15/25 (60%)
TM helix 3 109..139 CDD:320453 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 133..135 1/1 (100%)
TM helix 4 151..173 CDD:320453 7/21 (33%)
TM helix 5 192..221 CDD:320453 11/71 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..262 11/106 (10%)
TM helix 6 338..368 CDD:320453 13/40 (33%)
TM helix 7 379..404 CDD:320453 8/24 (33%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 396..400 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

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