DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and HRH2

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001354640.1 Gene:HRH2 / 3274 HGNCID:5183 Length:422 Species:Homo sapiens


Alignment Length:200 Identity:75/200 - (37%)
Similarity:121/200 - (60%) Gaps:5/200 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHC 146
            ||:|.|.|||::||||:...|||:|:||.|::|||||||::.:||:|...:..:...:..|...|
Human    27 VLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFC 91

  Fly   147 LTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS-LPLSL 210
            ..:..|||:.|||||::|..||:|||.::..|:|:....|..||.:.:|.:|::||.:| |.:.|
Human    92 NIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHL 156

  Fly   211 MYSKNHASVLVNGT---CQIP-DPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQ 271
            .::..:.:...|.|   |::. :.||.||..:|.||:||.:|.:||....::...|.:.:.....
Human   157 GWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISS 221

  Fly   272 TAAAT 276
            ..|||
Human   222 WKAAT 226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 72/189 (38%)
TM helix 1 75..101 CDD:320433 11/18 (61%)
TM helix 2 108..134 CDD:320433 13/25 (52%)
TM helix 3 146..176 CDD:320433 15/29 (52%)
TM helix 4 188..211 CDD:320433 8/23 (35%)
TM helix 5 229..258 CDD:320433 12/28 (43%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
HRH2NP_001354640.1 7tmA_Histamine_H2R 19..299 CDD:320179 74/199 (37%)
TM helix 1 20..46 CDD:320179 11/18 (61%)
TM helix 2 53..80 CDD:320179 13/26 (50%)
TM helix 3 91..121 CDD:320179 15/29 (52%)
TM helix 4 133..153 CDD:320179 7/19 (37%)
TM helix 5 179..209 CDD:320179 12/29 (41%)
TM helix 6 227..257 CDD:320179 74/199 (37%)
TM helix 7 267..292 CDD:320179
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340
Blue background indicates that the domain is not in the aligned region.

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