DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr2b

DIOPT Version :9

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_058946.2 Gene:Htr2b / 29581 RGDID:61801 Length:479 Species:Rattus norvegicus


Alignment Length:941 Identity:165/941 - (17%)
Similarity:258/941 - (27%) Gaps:546/941 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYW-ALLALVLVLGT 87
            :||:|     |.|:...|.|...::.....| .||..              :| |||...:::.|
  Rat    23 DHLIL-----TDRSGLKAESAAEEMKQTAEN-QGNTV--------------HWAALLIFAVIIPT 67

  Fly    88 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSEHCLTWIC 151
            ..|||||.||::.|:|||..|||||||||:.||:|.:.|||:.:||:: :..:||....|..|:.
  Rat    68 IGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLF 132

  Fly   152 LDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNH 216
            |||||.||||||||.||:|||::::.|::..:..:|....:||..|||:||.:::|:.:   |..
  Rat   133 LDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPI---KGI 194

  Fly   217 ASVLVNG---TCQIPDP---VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAA 275
            .:.:||.   ||::...   .:.|.||:..|:.||.:|::||.||:..|                
  Rat   195 EADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHAL---------------- 243

  Fly   276 TPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKE 340
                                                                             
  Rat   244 ----------------------------------------------------------------- 243

  Fly   341 PTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSH 405
                                                                             
  Rat   244 ----------------------------------------------------------------- 243

  Fly   406 HHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQR 470
                                                                            |
  Rat   244 ----------------------------------------------------------------R 244

  Fly   471 LRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDD 535
            .:||..|.|                                                        
  Rat   245 KKAYLVRNR-------------------------------------------------------- 253

  Fly   536 DDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQN 600
                                       |||:..:..::....:.|                    
  Rat   254 ---------------------------PPQRLTRWTVSTVLQRED-------------------- 271

  Fly   601 CVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGS 665
                       |:|          |||.:|.:|                                
  Rat   272 -----------SSF----------SSPEKMAML-------------------------------- 283

  Fly   666 TLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRT 730
                              |||                               |:           
  Rat   284 ------------------DGS-------------------------------HK----------- 288

  Fly   731 SLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSR 795
                  .|....|...|.:||.::              .|.|...|.|:                
  Rat   289 ------DKILPNSIDETLMRRMSS--------------AGKKPAQTISN---------------- 317

  Fly   796 NSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVV 860
                              ||:|:||||:||..|:::|.|||:.|:...:|..|.:.....:..:.
  Rat   318 ------------------EQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIF 364

  Fly   861 TWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWR------------------------ 901
            .|:||.||.|||:.||:|||.||:||.:.:.|.|.:|.:.:                        
  Rat   365 VWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTK 429

  Fly   902 --------PSRXQTPVKPGKLKTNTHKCASV 924
                    |:. |:||   :|:::|.:.:|:
  Rat   430 HGIRNGINPAMYQSPV---RLRSSTIQSSSI 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tm_1 90..>262 CDD:278431 77/178 (43%)
7tm_4 90..>238 CDD:304433 67/154 (44%)
Htr2bNP_058946.2 7tm_GPCRs 54..397 CDD:421689 145/825 (18%)
TM helix 1 55..81 CDD:410628 12/25 (48%)
TM helix 2 88..114 CDD:410628 16/25 (64%)
TM helix 3 127..157 CDD:410628 20/29 (69%)
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 134..139 4/4 (100%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 169..192 CDD:410628 8/25 (32%)
[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000250|UniProtKB:P41595 211..214 0/2 (0%)
TM helix 5 213..242 CDD:410628 11/28 (39%)
TM helix 6 316..346 CDD:410628 16/63 (25%)
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 336..340 2/3 (67%)
TM helix 7 358..383 CDD:410628 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 375..379 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P41595 477..479
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I1997
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 287 1.000 Inparanoid score I2747
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D408957at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X759
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.060

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