DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr2b

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_058946.2 Gene:Htr2b / 29581 RGDID:61801 Length:479 Species:Rattus norvegicus


Alignment Length:941 Identity:165/941 - (17%)
Similarity:258/941 - (27%) Gaps:546/941 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYW-ALLALVLVLGT 87
            :||:|     |.|:...|.|...::.....| .||..              :| |||...:::.|
  Rat    23 DHLIL-----TDRSGLKAESAAEEMKQTAEN-QGNTV--------------HWAALLIFAVIIPT 67

  Fly    88 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSEHCLTWIC 151
            ..|||||.||::.|:|||..|||||||||:.||:|.:.|||:.:||:: :..:||....|..|:.
  Rat    68 IGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLF 132

  Fly   152 LDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNH 216
            |||||.||||||||.||:|||::::.|::..:..:|....:||..|||:||.:::|:.:   |..
  Rat   133 LDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPI---KGI 194

  Fly   217 ASVLVNG---TCQIPDP---VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAA 275
            .:.:||.   ||::...   .:.|.||:..|:.||.:|::||.||:..|                
  Rat   195 EADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHAL---------------- 243

  Fly   276 TPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKE 340
                                                                             
  Rat   244 ----------------------------------------------------------------- 243

  Fly   341 PTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSH 405
                                                                             
  Rat   244 ----------------------------------------------------------------- 243

  Fly   406 HHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQR 470
                                                                            |
  Rat   244 ----------------------------------------------------------------R 244

  Fly   471 LRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDD 535
            .:||..|.|                                                        
  Rat   245 KKAYLVRNR-------------------------------------------------------- 253

  Fly   536 DDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQN 600
                                       |||:..:..::....:.|                    
  Rat   254 ---------------------------PPQRLTRWTVSTVLQRED-------------------- 271

  Fly   601 CVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGS 665
                       |:|          |||.:|.:|                                
  Rat   272 -----------SSF----------SSPEKMAML-------------------------------- 283

  Fly   666 TLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRT 730
                              |||                               |:           
  Rat   284 ------------------DGS-------------------------------HK----------- 288

  Fly   731 SLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSR 795
                  .|....|...|.:||.::              .|.|...|.|:                
  Rat   289 ------DKILPNSIDETLMRRMSS--------------AGKKPAQTISN---------------- 317

  Fly   796 NSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVV 860
                              ||:|:||||:||..|:::|.|||:.|:...:|..|.:.....:..:.
  Rat   318 ------------------EQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIF 364

  Fly   861 TWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWR------------------------ 901
            .|:||.||.|||:.||:|||.||:||.:.:.|.|.:|.:.:                        
  Rat   365 VWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTK 429

  Fly   902 --------PSRXQTPVKPGKLKTNTHKCASV 924
                    |:. |:||   :|:::|.:.:|:
  Rat   430 HGIRNGINPAMYQSPV---RLRSSTIQSSSI 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 82/200 (41%)
TM helix 1 75..101 CDD:320433 12/26 (46%)
TM helix 2 108..134 CDD:320433 16/25 (64%)
TM helix 3 146..176 CDD:320433 20/29 (69%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 11/31 (35%)
7tm_GPCRs <799..893 CDD:475119 34/93 (37%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
Htr2bNP_058946.2 7tm_GPCRs 54..397 CDD:475119 145/825 (18%)
TM helix 1 56..80 CDD:410628 11/23 (48%)
TM helix 2 89..111 CDD:410628 14/21 (67%)
TM helix 3 128..150 CDD:410628 15/21 (71%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 173..189 CDD:410628 7/15 (47%)
[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000250|UniProtKB:P41595 211..214 0/2 (0%)
TM helix 5 214..237 CDD:410628 8/22 (36%)
TM helix 6 322..344 CDD:410628 11/21 (52%)
TM helix 7 358..383 CDD:410628 10/24 (42%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 375..379 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P41595 477..479
Blue background indicates that the domain is not in the aligned region.

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