DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and drd3

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:XP_005162730.1 Gene:drd3 / 282554 ZFINID:ZDB-GENE-021119-1 Length:472 Species:Danio rerio


Alignment Length:892 Identity:179/892 - (20%)
Similarity:266/892 - (29%) Gaps:441/892 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 ASLGAYNDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFD 71
            ::|.|...||...|:.|||                          .:...||.:.::..|:.   
Zfish    16 STLMAMFSSGEWLWNDSEH--------------------------SFTPGGNYSPASGVEEA--- 51

  Fly    72 ANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGI-LTLV 135
            ..||:|:|..:|:|....||:|||:|:..||.||..|||.::|||:.||:||.||||..: |.:|
Zfish    52 KRNYYAMLYSLLILAIVFGNVLVCIAVLRERALQTTTNYLVVSLAVADLLVASLVMPWAVYLEVV 116

  Fly   136 KGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFG-RNKTRRRVTLKIVFVWL 199
            .|.:.....:|..::.|||:.|||||::||.||:|||.::..|:.:. .:.:|:||::.|..||:
Zfish   117 GGAWLFSRLYCNVFVTLDVMMCTASILNLCAISIDRYTAVVMPVLYNTTHSSRKRVSVMIATVWV 181

  Fly   200 LSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQ 264
            |:.|:|.||...::......:    |.|.:|.:.:..|:|.||:|..|.||.|......|.|:|:
Zfish   182 LAFAVSCPLLFGFNTTDDPAV----CSISNPDFVIYSSVVSFYLPFAVTLLVYVRIYIFLRRRRK 242

  Fly   265 NL----GGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLST 325
            .:    |.|:...|:.|          |::                                   
Zfish   243 KITFRQGSGKVQPASAP----------PSV----------------------------------- 262

  Fly   326 LDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQY 390
                |:.|.|.:.||                   .|.|                           
Zfish   263 ----EMCLQDDAHKE-------------------KRDL--------------------------- 277

  Fly   391 PSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRM 455
              ||.|.                                                  |.:..|: 
Zfish   278 --SPIRI--------------------------------------------------NVITESK- 289

  Fly   456 GGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNA 520
              ||      .:..||.|...||:.....|          |:..:..|..||           |.
Zfish   290 --EQ------VIRPRLLANCLRRKRPQTAP----------AENSLLPPVITL-----------NY 325

  Fly   521 LYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLP 585
            ......:...:..|.:.||||...::                                       
Zfish   326 CSISQASFARTEQDANREEEEGGDEE--------------------------------------- 351

  Fly   586 SVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAG 650
                         |..|:|.|||      ::....|..|..|                       
Zfish   352 -------------QVAVRSCEVK------KLANGRTHTSLRP----------------------- 374

  Fly   651 ITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDS 715
                              |.:||                   ...||.                 
Zfish   375 ------------------PRAAH-------------------AMVCPS----------------- 385

  Fly   716 SRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSP 780
                                                                             
Zfish   386 ----------------------------------------------------------------- 385

  Fly   781 CMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVC 845
                 |...||.||:                  |:|||::|.:|...|:|.|.||||.::|.|.|
Zfish   386 -----QARCRSMHSK------------------EKKATQMLAIVLGVFLICWLPFFVTHILNTHC 427

  Fly   846 AECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 892
            ..|  .|...|:...|||||.:|.:||:.||.||..||:||.|:|.|
Zfish   428 RAC--HIPPEVYSAFTWLGYVNSALNPVIYTTFNIEFRRAFIKILSC 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 76/198 (38%)
TM helix 1 75..101 CDD:320433 11/25 (44%)
TM helix 2 108..134 CDD:320433 15/26 (58%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 10/22 (45%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119 38/94 (40%)
TM helix 6 818..840 CDD:410628 10/21 (48%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
drd3XP_005162730.1 7tmA_D3_dopamine_R 54..466 CDD:320436 163/817 (20%)
TM helix 1 55..81 CDD:320436 11/25 (44%)
TM helix 2 88..111 CDD:320436 14/22 (64%)
TM helix 3 127..157 CDD:320436 16/29 (55%)
TM helix 4 172..190 CDD:320436 7/17 (41%)
TM helix 5 207..232 CDD:320436 10/24 (42%)
TM helix 6 394..424 CDD:320436 14/47 (30%)
TM helix 7 434..459 CDD:320436 11/24 (46%)

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