DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and adra2db

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_919346.1 Gene:adra2db / 266755 ZFINID:ZDB-GENE-021010-5 Length:415 Species:Danio rerio


Alignment Length:879 Identity:163/879 - (18%)
Similarity:247/879 - (28%) Gaps:468/879 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVL 83
            |.|:...|:....::|..|:|.....|:|.                       |:....|:..|:
Zfish     2 DLSTITFLLPNSSEDTNGTSAPRLPPHSQC-----------------------ASVLIVLVVTVI 43

  Fly    84 VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLT 148
            :|.|..||:||.:|:...|.|:...|.||:|||..|::||.||:|..:...|.||:.|||..|..
Zfish    44 ILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLAAADILVATLVIPFSLANEVMGYWYLGSTWCAF 108

  Fly   149 WICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYS 213
            ::.|||||||:||:|||.||:|||.|:...:.:...:|.||:.:.|..||::|..:|.|..||..
Zfish   109 YLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPRRIKIMITVVWVISAVISFPPLLMTK 173

  Fly   214 KNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPG 278
            .:....|:|.     :..|.|...||.|:.|..:|:|.||...| :|:||               
Zfish   174 HDELECLLNN-----ETWYILSSCIVSFFAPGLIMILVYCRIYR-VAKQR--------------- 217

  Fly   279 WASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTP 343
                                        ||:|..|.:                            
Zfish   218 ----------------------------ASTVFVAKN---------------------------- 226

  Fly   344 TTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHN 408
                                                                             
Zfish   227 ----------------------------------------------------------------- 226

  Fly   409 HQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRA 473
                                           |:||:.:::.....|.|                 
Zfish   227 -------------------------------GMERQPSQSETCFVRKG----------------- 243

  Fly   474 YKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDE 538
                                   ..:||:|:|    |...:...|..|            ||.|.
Zfish   244 -----------------------KSEVESPSS----HSSGSRERKGEL------------DDIDL 269

  Fly   539 EEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVK 603
            ||.|...:.:.::.              ||...:.|..            :||....|....|.:
Zfish   270 EESSVSNRHRNSRF--------------AKSRKVEGAQ------------SCPKPNGRLSWACSR 308

  Fly   604 SAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLS 668
            ::|:                     |.|                                     
Zfish   309 ASEL---------------------EQE------------------------------------- 315

  Fly   669 PHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLL 733
                                        |..|:||:||:                          
Zfish   316 ----------------------------PRARQLSLSKS-------------------------- 326

  Fly   734 LTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSS 798
                             :.|.:|                                          
Zfish   327 -----------------KLAQMR------------------------------------------ 332

  Fly   799 VISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISHWVFDVVTW 862
                           |::.|.||.||...||:.|.|||....|..:|.: |  .|...:|::..|
Zfish   333 ---------------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAICRKSC--TIPDSLFNLFFW 380

  Fly   863 LGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS 896
            :||.:|.||||.|||||:.||:||||: :||:|:
Zfish   381 IGYCNSSVNPIIYTIFNRDFRKAFKKI-MCRHST 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 75/192 (39%)
TM helix 1 75..101 CDD:320433 9/25 (36%)
TM helix 2 108..134 CDD:320433 12/25 (48%)
TM helix 3 146..176 CDD:320433 19/29 (66%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119 36/94 (38%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 12/24 (50%)
adra2dbNP_919346.1 7tmA_alpha-2D_AR 59..404 CDD:320447 138/787 (18%)
TM helix 2 68..94 CDD:320447 12/25 (48%)
TM helix 3 106..136 CDD:320447 19/29 (66%)
TM helix 4 148..171 CDD:320447 8/22 (36%)
TM helix 5 184..213 CDD:320447 11/29 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..299 20/146 (14%)
TM helix 6 331..361 CDD:320447 13/86 (15%)
TM helix 7 372..397 CDD:320447 12/24 (50%)

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