DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2B and adra2da

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_919345.2 Gene:adra2da / 266754 ZFINID:ZDB-GENE-021010-4 Length:408 Species:Danio rerio


Alignment Length:830 Identity:152/830 - (18%)
Similarity:221/830 - (26%) Gaps:460/830 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLG 142
            |:..:::|.|..||:||.:|:...|.|:...|.||:|||..|::||.||:|..:...:.||:..|
Zfish    35 LVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANEIMGYWYFG 99

  Fly   143 SEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP 207
            |..|..::.|||||||:||:|||.||:|||.|:...:|:...:|.||:...|..|||:|..:|.|
Zfish   100 STWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIKCMIAVVWLISAVISFP 164

  Fly   208 LSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQT 272
            ..:|...:....|:|     .:..|.|....|.|:.|..:|:..||...| :|:||         
Zfish   165 PLIMTKHDEKECLIN-----DETWYILSSCAVSFFAPGLIMITVYCKIYR-VAKQR--------- 214

  Fly   273 AAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSS 337
                                              :|:|..|                        
Zfish   215 ----------------------------------SSTVFVA------------------------ 221

  Fly   338 IKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQ 402
                                  ..|||...|.|.|....|.:|                      
Zfish   222 ----------------------KNGLERQPSQSETCFVRKDKF---------------------- 242

  Fly   403 QSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERES-TRNSLASSRMGGEQSDGTLSQ 466
                                                   |:|| :.||               |:
Zfish   243 ---------------------------------------EKESPSSNS---------------SE 253

  Fly   467 LSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQES 531
            .:||                                                          ||.
Zfish   254 SAQR----------------------------------------------------------QEE 260

  Fly   532 LDDDDDEEEESAQQKDQQTK-SKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595
            |||.|.||..::..:.:.:: ||....:.|...||::  |.::...||.                
Zfish   261 LDDIDLEESAASDSRARGSRFSKRRRVEGERRGPQRS--CRVSWAAHQE---------------- 307

  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660
                                                                             
Zfish   308 ----------------------------------------------------------------- 307

  Fly   661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725
                                                ||.|:..::..:.|               
Zfish   308 ------------------------------------PGSRQQQLASKSKV--------------- 321

  Fly   726 GGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVR 790
                                       |.:|                                  
Zfish   322 ---------------------------AQMR---------------------------------- 325

  Fly   791 SHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISH 854
                                   |::.|.||.||...||:.|.|||....|..||.| |..  ..
Zfish   326 -----------------------EKRFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGP--PE 365

  Fly   855 WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSR 904
            .:|.:..|:||.:|.||||.|||||:.||:|||||:        .|...|
Zfish   366 ALFKLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKVV--------CWSAQR 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 71/188 (38%)
TM helix 1 75..101 CDD:320433 8/22 (36%)
TM helix 2 108..134 CDD:320433 12/25 (48%)
TM helix 3 146..176 CDD:320433 19/29 (66%)
TM helix 4 188..211 CDD:320433 9/22 (41%)
TM helix 5 229..258 CDD:320433 8/28 (29%)
7tm_GPCRs <799..893 CDD:475119 38/94 (40%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 12/24 (50%)
adra2daNP_919345.2 7tmA_alpha-2D_AR 44..397 CDD:320447 143/801 (18%)
TM helix 2 65..91 CDD:320447 12/25 (48%)
TM helix 3 103..133 CDD:320447 19/29 (66%)
TM helix 4 145..168 CDD:320447 9/22 (41%)
TM helix 5 181..210 CDD:320447 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..306 23/199 (12%)
TM helix 6 324..354 CDD:320447 13/86 (15%)
TM helix 7 365..390 CDD:320447 12/24 (50%)

Return to query results.
Submit another query.