DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ser-6

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_741350.1 Gene:ser-6 / 259560 WormBaseID:WBGene00021897 Length:401 Species:Caenorhabditis elegans


Alignment Length:826 Identity:131/826 - (15%)
Similarity:216/826 - (26%) Gaps:446/826 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 LLALVLVLG-----TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKG 137
            ::.|.|.||     ...||:||...|..::.||..||:.::||.|:||::.:|::|..|:.....
 Worm     1 MILLSLTLGVVNCFVVIGNLLVFYVILTKKSLQTSTNHLVLSLTISDLLLGILILPFAIIQEHSN 65

  Fly   138 YFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSI 202
            .:..|...|..|:.:||...||||.:|..||.|||:::|.|:::....:.:.|.|....||..|:
 Worm    66 EWIFGHFGCRLWLSVDVFLSTASIYNLLAISFDRYMAVRQPIKYPIISSTKVVRLMTFLVWFCSL 130

  Fly   203 AMSLPLSLMYSKNHASVLVNGTCQ---IPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQ 264
            .:::.|.::.:.|.........||   :|. :|.:..::..|.:|..||::   |.||:.     
 Worm   131 LLAVILFVLLTLNAHDSEPTKDCQPTSLPS-MYIIFSAMASFIVPAFVMVI---LNVRIF----- 186

  Fly   265 NLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNH 329
                                                       .:|||                 
 Worm   187 -------------------------------------------QTVLH----------------- 191

  Fly   330 ELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSP 394
                        |..|||...:.|:  |::.|..|.:.       |.|                 
 Worm   192 ------------TSRTMTVKSKNGS--LRVHRRKEPII-------PVK----------------- 218

  Fly   395 QRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQ 459
                         .|.::                                               
 Worm   219 -------------KHDKY----------------------------------------------- 223

  Fly   460 SDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPR 524
                                        |.|..||  :|.|.:|:..:                 
 Worm   224 ----------------------------ETRLSHE--EECVGSPSKEV----------------- 241

  Fly   525 HTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDP-PQKAKQCHIAGQNHQSDYLQLPSVC 588
                                                :|| |..|    :..::|:|..:..|:: 
 Worm   242 ------------------------------------IDPIPVVA----VVEKHHKSSAVDAPAI- 265

  Fly   589 TCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITG 653
                                                               :..||.:|..|:  
 Worm   266 ---------------------------------------------------RSFLTHTVVFGV-- 277

  Fly   654 GPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRH 718
                                                            |...||..:        
 Worm   278 ------------------------------------------------LEAKKTNII-------- 286

  Fly   719 RRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCML 783
                                     |..|...|.:|:||               ...:|...|| 
 Worm   287 -------------------------NHITQWWRRSTVRS---------------PNPSTRKKCM- 310

  Fly   784 QRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLP-----T 843
                                    .|.:|.|.:..:..|:|...|::.|.||..:.:|.     |
 Worm   311 ------------------------RRSLRTEIRVARTTGIVVAAFIVCWIPFTTIYVLQAYAVCT 351

  Fly   844 VCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKV 889
            |.|.|   |...:|....||||::|.||||.|..|::.||.|.|::
 Worm   352 VAAGC---IPASLFTTAFWLGYSNSAVNPILYAAFSRDFRIALKRL 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 56/196 (29%)
TM helix 1 75..101 CDD:320433 9/27 (33%)
TM helix 2 108..134 CDD:320433 10/25 (40%)
TM helix 3 146..176 CDD:320433 14/29 (48%)
TM helix 4 188..211 CDD:320433 6/22 (27%)
TM helix 5 229..258 CDD:320433 7/28 (25%)
7tm_GPCRs <799..893 CDD:475119 31/96 (32%)
TM helix 6 818..840 CDD:410628 6/21 (29%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
ser-6NP_741350.1 7tmA_amine_R-like 3..391 CDD:320098 129/819 (16%)
TM helix 1 3..29 CDD:320098 9/25 (36%)
TM helix 2 36..63 CDD:320098 10/26 (38%)
TM helix 3 74..104 CDD:320098 14/29 (48%)
TM helix 4 116..136 CDD:320098 5/19 (26%)
TM helix 5 158..314 CDD:320098 54/584 (9%)
TM helix 6 315..345 CDD:320098 8/29 (28%)
TM helix 7 359..384 CDD:320098 11/24 (46%)

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