Protein Alignment 5-HT2B and Drd2

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_036679.1
• Gene: Drd2 / 24318
• RGDID: 2520
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 867
• Identity: 173/867 - (19%)
• Similarity: 259/867 - (29%)
• Gaps: 433/867 - (49%)

  Fly    29 WEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNIL 93
            |.:|:.:|              ..|:...|.  |....|.|.  .||:|:|..:|:.....||:|
  Rat     8 WYDDDLER--------------QNWSRPFNG--SEGKADRPH--YNYYAMLLTLLIFIIVFGNVL 54

  Fly    94 VCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCT 158
            ||:|::.|:.||..|||.::|||:.||:||.||||..:...|.|.:.....||..::.|||:.||
  Rat    55 VCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCT 119

  Fly   159 ASIMHLCTISVDRYLSLRYPMRFG-RNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVN 222
            |||::||.||:|||.::..||.:. |..::||||:.|..||:||..:|.|  |::..|:..   .
  Rat   120 ASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCP--LLFGLNNTD---Q 179

  Fly   223 GTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQA 287
            ..|.|.:|.:.:..|||.||:|..|.||.|.....:|.::|:.:
  Rat   180 NECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRV--------------------- 223

  Fly   288 PALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQF 352
                              |......|..||                    :|.|.....|
  Rat   224 ------------------NTKRSSRAFRAN--------------------LKTPLKGNCT----- 245

  Fly   353 GAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVY 417
                                                                       ||
  Rat   246 -----------------------------------------------------------HP---- 247

  Fly   418 HQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASS 482
                                                                             
  Rat   248 ----------------------------------------------------------------- 247

  Fly   483 AVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKD 547
                           ||::..|..:   |.:.|.|.|         :..:|         |.::.
  Rat   248 ---------------EDMKLCTVIM---KSNGSFPVN---------RRRMD---------AARRA 276

  Fly   548 QQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISS 612
            |:.:.::..|.:   ||::.:...|...:||   |.||
  Rat   277 QELEMEMLSSTS---PPERTRYSPIPPSHHQ---LTLP--------------------------- 308

  Fly   613 AFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGS 677
                         .||.                                        |..|:...
  Rat   309 -------------DPSH----------------------------------------HGLHSNPD 320

  Fly   678 SLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATT 742
            |             |..|                  :.:.|.:            ::.|
  Rat   321 S-------------PAKP------------------EKNGHAK------------IVNP------ 336

  Fly   743 SNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTT--TSSPCMLQRQQTVRSHHSRNSSVISRNSS 805
                    |.|.....|.|.       .|||||:  |.|...|.:|:
  Rat   337 --------RIAKFFEIQTMP-------NGKTRTSLKTMSRRKLSQQK------------------ 368

  Fly   806 RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMV 870
                    |:|||::|.:|...|:|.|.|||:.::|...| :|  .|...::...|||||.:|.|
  Rat   369 --------EKKATQMLAIVLGVFIICWLPFFITHILNIHC-DC--NIPPVLYSAFTWLGYVNSAV 422

  Fly   871 NPIFYTIFNKVFRQAFKKVLLC 892
            |||.||.||..||:||.|:|.|
  Rat   423 NPIIYTTFNIEFRKAFMKILHC 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	78/193 (40%)
		TM helix 1	75..101	CDD:320433	10/25 (40%)
		TM helix 2	108..134	CDD:320433	14/25 (56%)
		TM helix 3	146..176	CDD:320433	16/29 (55%)
		TM helix 4	188..211	CDD:320433	11/22 (50%)
		TM helix 5	229..258	CDD:320433	11/28 (39%)
		7tm_GPCRs	<799..893	CDD:475119	37/94 (39%)
		TM helix 6	818..840	CDD:410628	9/21 (43%)
		TM helix 7	854..879	CDD:410628	12/24 (50%)
Drd2	NP_036679.1	7tmA_D2_dopamine_R	35..438	CDD:320435	160/814 (20%)
		TM helix 1	36..62	CDD:320435	10/25 (40%)
		TM helix 2	69..92	CDD:320435	14/22 (64%)
		TM helix 3	107..137	CDD:320435	16/29 (55%)
		TM helix 4	152..170	CDD:320435	9/19 (47%)
		TM helix 5	186..211	CDD:320435	11/24 (46%)
		Interaction with PPP1R9B. /evidence=ECO:0000269|PubMed:10391935	211..374		55/566 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		16/163 (10%)
		TM helix 6	367..397	CDD:320435	13/55 (24%)
		TM helix 7	406..431	CDD:320435	12/24 (50%)