Protein Alignment 5-HT2B and dop-3

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001024908.2
• Gene: dop-3 / 188499
• WormBaseID: WBGene00020506
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 869
• Identity: 185/869 - (21%)
• Similarity: 294/869 - (33%)
• Gaps: 339/869 - (39%)

  Fly    76 WALLA---LVLVLGTAA-GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVK 136
            |.:.|   |.||...|. ||:||.:::..||.||.|||..::|||::|.|||:.||..|:
 Worm    20 WRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMSFGV----- 79

  Fly   137 GYFP-------LGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTR-RRVTLK 193
             |:.       |||..|..:..|||...||||::|..||:|||:::.:|:.:.:...| .|..:.
 Worm    80 -YYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAMIS 143

  Fly   194 IVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRL 258
            |..||.:|:|::|||.|..:....:.|..  |::.:|.:.::.||..|:||...|::.|.:..|.
 Worm   144 ITIVWGVSVAVALPLLLGVNPMEENDLQE--CELANPYFNMISSIFSFFIPCIAMIILYTIIFRR 206

  Fly   259 LARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDL 323
            | |||:....               |.||...|.......||  |....:..:..|..|.||..|
 Worm   207 L-RQRERARS---------------LRQAQRSENDKISSALL--GGAQIARQMGKHFKNRTDQIL 253

  Fly   324 STLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQL 388
            ..:                                         |..|:..||.||.|
 Worm   254 LEI-----------------------------------------SFQTSSFPTMSESS------- 270

  Fly   389 QYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASS 453
                                          :.||
 Worm   271 ------------------------------EDAS------------------------------- 274

  Fly   454 RMGGEQSDGTLSQLSQRLRAY--KKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSL 516
                     |:|.:......:  ||....|:::|                             ::
 Worm   275 ---------TISPMINSFNNFLPKKTPYPSTSIP-----------------------------AI 301

  Fly   517 PKNALYPRHTTVQESLDDDDDEEE-------ESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAG 574
            |:....|..|.::.  .:.:.|:|       ::.:..|.:..|.|
 Worm   302 PECGSMPNLTIIER--PEAEKEKEISIMDLRDTVEMLDDKYSSAI-------------------- 344

  Fly   575 QNHQSDYLQLPSVCTCPYFGDR-----PL---QNCVKSAEVKIISSAFRVTTTTTAVSSSPSEME 631
                     |.|..|...||:.     |.   .|.||.:..::.::... |:||..:...|....
 Worm   345 ---------LTSFQTSRSFGEELEEILPFIDGSNSVKHSREQLHTTRSN-TSTTRLLDVKPELRS 399

  Fly   632 LLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGT-- 694
            :.:.|..::|.|:..                  |...|.|..|                  ||
 Worm   400 ISVPSIQDEKKLSQK------------------SNDLPFSHQN------------------GTHK 428

  Fly   695 ----PCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTS-NSSTPLRRSAT 754
                |.||    .:.|:.|                    |:||.|.....|.| |.::..:..|.
 Worm   429 QKLLPNPG----ILMKSKS--------------------TTLLKTNGYMDTDSLNRNSHKKSLAD 469

  Fly   755 LRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISR--------NSSRH---- 807
            |.::...::                      ..::|.:.:|....:||        ..|||
 Worm   470 LLANDEFSF----------------------SDSMRVYKNRLFKSLSRATSGWNKPRPSRHMVKK 512

  Fly   808 -GRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEER---ISHWVFDVVTWLGYASS 868
             .:.:|.|.|||..|.||...|:..|.|||||:|..::|...:|.   :......:.|||||.:|
 Worm   513 ATKQMRREHKATVTLAVVLAVFLFCWLPFFVLHLSNSICLIIDENSACVGFLPLYLATWLGYLNS 577

  Fly   869 MVNPIFYTIFNKVFRQAFKKVLLC 892
            .:||:.||:|::.||.||:.:|.|
 Worm   578 SLNPLIYTVFDQRFRNAFRNILSC 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	72/202 (36%)
		TM helix 1	75..101	CDD:320433	10/28 (36%)
		TM helix 2	108..134	CDD:320433	12/25 (48%)
		TM helix 3	146..176	CDD:320433	14/29 (48%)
		TM helix 4	188..211	CDD:320433	9/22 (41%)
		TM helix 5	229..258	CDD:320433	8/28 (29%)
		7tm_GPCRs	<799..893	CDD:475119	40/110 (36%)
		TM helix 6	818..840	CDD:410628	11/21 (52%)
		TM helix 7	854..879	CDD:410628	10/24 (42%)
dop-3	NP_001024908.2	7tmA_D2-like_dopamine_R	22..>204	CDD:320181	66/189 (35%)
		TM helix 1	23..49	CDD:320181	9/25 (36%)
		TM helix 2	56..82	CDD:320181	13/31 (42%)
		TM helix 3	95..125	CDD:320181	14/29 (48%)
		TM helix 4	138..161	CDD:320181	9/22 (41%)
		TM helix 5	177..204	CDD:320181	8/26 (31%)
		7tm_GPCRs	<515..595	CDD:475119	31/79 (39%)
		TM helix 6	524..546	CDD:410628	11/21 (52%)
		TM helix 7	563..588	CDD:410628	10/24 (42%)