DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and dop-4

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_508238.2 Gene:dop-4 / 183715 WormBaseID:WBGene00016872 Length:517 Species:Caenorhabditis elegans


Alignment Length:862 Identity:175/862 - (20%)
Similarity:274/862 - (31%) Gaps:405/862 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 NATISATFEDVPFDANNYW--ALLALVL---VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAI 117
            :.|:.||.|    .|...|  .|||:.|   .|.|.|||.||.:|:..::.|:|.|.|.::||||
 Worm    26 DTTVWATEE----PAAIVWRHPLLAIALFSICLLTVAGNCLVVIAVCTKKYLRNPTGYLIISLAI 86

  Fly   118 TDLMVAVLVMPLGILTLVKGY-FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF 181
            .||:|.|:|||:..|..:..: :..|...|..:..:|:|..||||.:||.||:|||::.:.|:.:
 Worm    87 ADLIVGVIVMPMNSLFEIANHTWLFGLMMCDVFHAMDILASTASIWNLCVISLDRYMAGQDPIGY 151

  Fly   182 GRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLV--NGTCQIPD-PVYKLVGSIVCFYI 243
            ....::||:.:.|:.||:||..:|.| .:::.:..:..|.  ...|...| .:|....|:|.|||
 Worm   152 RDKVSKRRILMAILSVWVLSAILSFP-GIIWWRTSSPHLYEDQSQCLFTDSKMYVSFSSLVSFYI 215

  Fly   244 PLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNAS 308
            ||.::|..|.....:..|..:.:..|.:|.:                         :|...|..|
 Worm   216 PLFLILFAYGKVYIIATRHSKGMRMGIKTVS-------------------------IKKRNGKKS 255

  Fly   309 SVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTG 373
                     :|:|: |.|         ||..|||    ..:| ||       ||.:|  |||...
 Worm   256 ---------NTETE-SIL---------SSENEPT----LRIH-FG-------RGKQS--SSSLRN 287

  Fly   374 SPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTT 438
            |                     |:.|                                       
 Worm   288 S---------------------RFHA--------------------------------------- 292

  Fly   439 LGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETP 503
                |||||.              .|.|:|                                   
 Worm   293 ----RESTRL--------------LLKQVS----------------------------------- 304

  Fly   504 TSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAK 568
            ..:|.....||:         :.||::.|                ...::.||||:    ..::.
 Worm   305 CKSLNDRGEHNN---------NNTVRQPL----------------LRGTEGCHSDS----ISRSS 340

  Fly   569 QCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELL 633
            |.:..|:|     :.:.|.|                             ::|......|..|.| 
 Worm   341 QRNFRGRN-----VTIGSNC-----------------------------SSTLLQVDQPDRMSL- 370

  Fly   634 MCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPG 698
              ||.::..:||.:|.                                                 
 Worm   371 --SSNSQMVMTSPLST------------------------------------------------- 384

  Fly   699 RRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNY 763
            ||||::.:                                                 :|.|.|.|
 Worm   385 RRKLNVRE-------------------------------------------------KSRQMMRY 400

  Fly   764 QGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTF 828
            .                                          |      ||:|.:.|.:|...|
 Worm   401 V------------------------------------------H------EQRAARTLSIVVGAF 417

  Fly   829 VILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
            ::.|:||||...|...|..|... ...:|..|||.|:.:||:||:.|:.|::.||:|||::|.|:
 Worm   418 ILCWTPFFVFTPLTAFCESCFSN-KETIFTFVTWAGHLNSMLNPLIYSRFSRDFRRAFKQILTCQ 481

  Fly   894 YSSTSAWRPSRXQTPVK 910
                   |..: :|..|
 Worm   482 -------RQQKVKTAFK 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 68/201 (34%)
TM helix 1 75..101 CDD:320433 13/30 (43%)
TM helix 2 108..134 CDD:320433 14/25 (56%)
TM helix 3 146..176 CDD:320433 14/29 (48%)
TM helix 4 188..211 CDD:320433 9/22 (41%)
TM helix 5 229..258 CDD:320433 11/29 (38%)
7tm_GPCRs <799..893 CDD:475119 32/93 (34%)
TM helix 6 818..840 CDD:410628 8/21 (38%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
dop-4NP_508238.2 7tmA_Dop1R2-like 44..474 CDD:320195 161/814 (20%)
TM helix 1 44..70 CDD:320195 12/25 (48%)
TM helix 2 77..103 CDD:320195 14/25 (56%)
TM helix 3 116..146 CDD:320195 14/29 (48%)
TM helix 4 158..180 CDD:320195 9/22 (41%)
TM helix 5 201..230 CDD:320195 10/28 (36%)
TM helix 6 401..431 CDD:320195 12/77 (16%)
TM helix 7 442..467 CDD:320195 10/24 (42%)

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