DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2B and ser-2

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001024339.1 Gene:ser-2 / 182110 WormBaseID:WBGene00004777 Length:455 Species:Caenorhabditis elegans


Alignment Length:887 Identity:158/887 - (17%)
Similarity:250/887 - (28%) Gaps:474/887 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALV-LVL 85
            |.:.:||...|..:.:..||:|           |....|:...  |:|..:....:::..| |||
 Worm     8 SVQEMVLRAIDSIRDSVINASS-----------AVSTTTLPPL--DIPMTSMKPPSIIPTVELVL 59

  Fly    86 G----------TAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILT-LVKGYF 139
            |          |..||.||.:|:...|.|:.|.||||:|||.:||.||:.||||.::| |..|.:
 Worm    60 GTITYLVIIAMTVVGNTLVVVAVFSYRPLKKVQNYFLVSLAASDLAVAIFVMPLHVVTFLAGGKW 124

  Fly   140 PLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM 204
            .||...|..:...|:|.||:||::||.|::|||.::..|:.:.:.:|.:.|.:.||.||:||:.:
 Worm   125 LLGVTVCQFFTTADILLCTSSILNLCAIALDRYWAIHNPINYAQKRTTKFVCIVIVIVWILSMLI 189

  Fly   205 SLPLSLMYSKNHASVLVNGTCQIPDP----VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQN 265
            |:|..:.:: |....::..:|.:...    |:...||   |::||.||::.| :.:.:.||||..
 Worm   190 SVPPIIGWN-NWQENMMEDSCGLSTEKAFVVFSAAGS---FFLPLLVMVVVY-VKIFISARQRIR 249

  Fly   266 LGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHE 330
            ...|:                                     |:::...:|...|          
 Worm   250 TNRGR-------------------------------------SALMRIQNAEGDD---------- 267

  Fly   331 LWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQ 395
                                    :..|:|                                   
 Worm   268 ------------------------DYRKMS----------------------------------- 273

  Fly   396 RYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQS 460
                                                         |:|.|..::..|||: ||::
 Worm   274 ---------------------------------------------IKRASVESARTSSRV-GEKT 292

  Fly   461 DGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRH-NSLPKNALYPR 524
            ...::                                 |.:|..:||..|... .|||       
 Worm   293 PLVIA---------------------------------DGQTTVTTLAAHSTDGGSLP------- 317

  Fly   525 HTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCT 589
                                 ||:.||                   |:...|:.|          
 Worm   318 ---------------------KDETTK-------------------HMKYHNNGS---------- 332

  Fly   590 CPYFGDRPLQNC-VKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITG 653
                       | ||..:||                    |.|                      
 Worm   333 -----------CKVKVKDVK--------------------EDE---------------------- 344

  Fly   654 GPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRH 718
                                                   |.|.|                     
 Worm   345 ---------------------------------------GNPNP--------------------- 349

  Fly   719 RRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCML 783
                                             :|.||..:.::                     
 Worm   350 ---------------------------------TAVLRKREKIS--------------------- 360

  Fly   784 QRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAEC 848
                                       :..|::|.|.:.|:.|.|...|.||||..::...|..|
 Worm   361 ---------------------------VAKEKRAAKTIAVIIFVFSFCWLPFFVAYVIRPFCETC 398

  Fly   849 EERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 890
              ::...|....|||||.:|.:||..|.|.|..||:||||:|
 Worm   399 --KLHAKVEQAFTWLGYINSSLNPFLYGILNLEFRRAFKKIL 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 73/208 (35%)
TM helix 1 75..101 CDD:320433 11/36 (31%)
TM helix 2 108..134 CDD:320433 16/26 (62%)
TM helix 3 146..176 CDD:320433 13/29 (45%)
TM helix 4 188..211 CDD:320433 9/22 (41%)
TM helix 5 229..258 CDD:320433 9/32 (28%)
7tm_GPCRs <799..893 CDD:475119 32/92 (35%)
TM helix 6 818..840 CDD:410628 9/21 (43%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
ser-2NP_001024339.1 7tmA_tyramine_octopamine_R-like 58..434 CDD:320188 140/818 (17%)
TM helix 1 59..85 CDD:320188 8/25 (32%)
TM helix 2 92..118 CDD:320188 15/25 (60%)
TM helix 3 131..161 CDD:320188 13/29 (45%)
TM helix 4 173..196 CDD:320188 9/22 (41%)
TM helix 5 214..243 CDD:320188 9/32 (28%)
TM helix 6 362..392 CDD:320188 11/29 (38%)
TM helix 7 402..427 CDD:320188 11/24 (46%)

Return to query results.
Submit another query.