DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and DRD3

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000787.2 Gene:DRD3 / 1814 HGNCID:3024 Length:400 Species:Homo sapiens


Alignment Length:823 Identity:153/823 - (18%)
Similarity:228/823 - (27%) Gaps:458/823 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 YWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGI-LTLVKGY 138
            |:||....|:|....||.|||:|:..||.||..|||.::|||:.||:||.||||..: |.:..|.
Human    31 YYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGV 95

  Fly   139 FPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF--GRNKTR-RRVTLKIVFVWLL 200
            :......|..::.|||:.|||||::||.||:|||.::..|:.:  |..::. |||.|.|..||:|
Human    96 WNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVL 160

  Fly   201 SIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYC-LTVRLLARQRQ 264
            :.|:|.||...::......:    |.|.:|.:.:..|:|.||:|.||.:|.|. :.|.|..|:|:
Human   161 AFAVSCPLLFGFNTTGDPTV----CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRK 221

  Fly   265 NLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNH 329
            .:                       |.|:.:....::||                          
Human   222 RI-----------------------LTRQNSQCNSVRPG-------------------------- 237

  Fly   330 ELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSP 394
               .|..:: .|.|.                                        ||:|      
Human   238 ---FPQQTL-SPDPA----------------------------------------HLEL------ 252

  Fly   395 QRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQ 459
            :||.:..|                                                 .:.:||  
Human   253 KRYYSICQ-------------------------------------------------DTALGG-- 266

  Fly   460 SDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPR 524
                                     ||.::|.|            ...|..|..|||        
Human   267 -------------------------PGFQERGG------------ELKREEKTRNSL-------- 286

  Fly   525 HTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCT 589
                                                                             
Human   287 ----------------------------------------------------------------- 286

  Fly   590 CPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGG 654
                                                ||                           
Human   287 ------------------------------------SP--------------------------- 288

  Fly   655 PAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHR 719
                       |::|                               |||:..             
Human   289 -----------TIAP-------------------------------KLSLEV------------- 298

  Fly   720 RRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQ 784
             |..|.|.:.|||.|.|.:.     ...|||                                  
Human   299 -RKLSNGRLSTSLKLGPLQP-----RGVPLR---------------------------------- 323

  Fly   785 RQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECE 849
                                         |:|||:::.:|...|::.|.|||:.::|.|.|..| 
Human   324 -----------------------------EKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTC- 358

  Fly   850 ERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 892
             .:|..::...|||||.:|.:||:.||.||..||:||.|:|.|
Human   359 -HVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 77/196 (39%)
TM helix 1 75..101 CDD:320433 11/25 (44%)
TM helix 2 108..134 CDD:320433 15/26 (58%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 12/22 (55%)
TM helix 5 229..258 CDD:320433 11/29 (38%)
7tm_GPCRs <799..893 CDD:475119 34/94 (36%)
TM helix 6 818..840 CDD:410628 7/21 (33%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
DRD3NP_000787.2 7tmA_D3_dopamine_R 30..394 CDD:320436 148/815 (18%)
TM helix 1 31..57 CDD:320436 11/25 (44%)
TM helix 2 64..87 CDD:320436 14/22 (64%)
TM helix 3 103..133 CDD:320436 16/29 (55%)
TM helix 4 150..168 CDD:320436 8/17 (47%)
TM helix 5 185..210 CDD:320436 10/24 (42%)
TM helix 6 322..352 CDD:320436 12/92 (13%)
TM helix 7 362..387 CDD:320436 10/24 (42%)

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