Protein Alignment 5-HT2B and dop-2

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_001256126.1
• Gene: dop-2 / 179347
• WormBaseID: WBGene00001053
• Length: 849
• Species: Caenorhabditis elegans
• Alignment Length: 995
• Identity: 214/995 - (21%)
• Similarity: 373/995 - (37%)
• Gaps: 275/995 - (27%)

  Fly    17 GDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFEDVPFDANNYWALLAL 81
            |:.|:.|   :.|.......:|...|.               :||..:  .:|.   ||..|..:
 Worm     4 GETWNVS---LEWPPPSLDLSTITQTP---------------STIVGS--GIPL---NYAGLSLI 45

  Fly    82 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSEH 145
            |:.|.|..||:||.:::...|.||:..|:.::.||:.||:||::|||..:...| .|.:.||:..
 Worm    46 VIPLITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAVYVYVTNGDWYLGNLM 110

  Fly   146 CLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGR-NKTRRRVTLKIVFVWLLSIAMSLPLS 209
            |..::..||...||||:.|..||.|||.::..|:::.| ::..:||...|..:||:|:.::.|
 Worm   111 CDIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYSRQSQNVKRVWTLIAVIWLVSLTLASP-- 173

  Fly   210 LMYSKNHASVLVNG-TCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQ----------- 262
            :::..|......|. .|:..:..:.::.|::.|.||..::|..|...:..|.::
 Worm   174 MVFGVNVRPPDANPYECRFYNAEFSILSSMISFVIPCFLVLFVYIRIIIALKKREKAAKMRREKN 238

  Fly   263 --------RQNLGGGQQTAAATPGWASG-----WLGQAPALERRCTWRRLLKPGPGNASSVLHAH 314
                    |.:.|..|....|.....:|     .:...|::.||      ::....:..::..|.
 Worm   239 TIAHGLTMRPDTGEEQVDEEAAGRIVAGPVVNVMMAALPSMTRR------MRQFERHRRAIELAG 297

  Fly   315 SANSTDTDLSTL----------DNHELWLPDSS---IKEPTPTTMTALHQFGAEMLKLSRGLESV 366
            .....:.:|..:          |:.:.:..|:.   ::...|.|.:.|           |.:.:.
 Worm   298 DEEWEEDELDVMDECCGGDDAGDDDDDYHADNGQGVVEASAPRTTSML-----------RRIINA 351

  Fly   367 ASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTV 431
            ||..|..|..:|..|.|.                           .|| .:.|..|......::.
 Worm   352 ASVGTANSTAQSVASASG---------------------------MPA-FFAQNISTTSPSSSSC 388

  Fly   432 LGLSTTTLGIERES---TRNSLASSRMGGEQSD--GTLSQLSQRLRAYKKRRRASSAVPGREKRA 491
            ...:|||..|.:.|   ....|.:.|..|..|.  .:|..||:.:... .....|.......:|:
 Worm   389 ARTTTTTSAIPKASGDLPLPMLLNEREFGNSSTPRSSLESLSENVNVI-TNDFVSENCTTFSRRS 452

  Fly   492 GHEDADEDVETPTS-------TLRRHKRHNSLPKNALYPRHTTVQE-------------SLDDDD 536
            .:.|..:...:.||       :::..||..:|.:|.....|..|.:             |:.:..
 Worm   453 SYADDSQPTSSQTSSGDGRSYSIKGQKRFRNLSRNYSTKHHRKVVKVNRGNSRNNSRTASITNQS 517

  Fly   537 DEEEESA--------------QQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSV 587
            |:....|              :.|....|..:..::...:||::.::..:
 Worm   518 DDALIPAIIRTISRKSPRLFRRDKTDIKKHSMILANPITEPPKEYRRVSM--------------- 567

  Fly   588 CTCPYFGDRPLQNCVKSAEVKIISSA---FRVTTTTTAVSSSPSEMELLMCSSGNKK---SLTSS 646
                     |:.......|.:.||::   ..:.|||.:.|::.:..|||......:|   .:|.:
 Worm   568 ---------PIHPTNSQTETETISASRDIENLPTTTISRSTTANSAELLGSPDDFEKFPALITET 623

  Fly   647 VSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTV-QSDGSGYLAAPGTPCPGRRKLSISKTASV 710
            |...:      .|....|..:.|    ....:||| :.:|:.              |:..|..||
 Worm   624 VLEDV------LAETREGCFMQP----TVSFALTVREMEGNA--------------LNNLKGCSV 664

  Fly   711 VTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSH---QNMNYQGAGECGGK 772
               :|||           |.|.:..|......:..|.|         |   |.|:..|. .|..|
 Worm   665 ---ESSR-----------RVSQVDPPLAIQILTRPSLP---------HLDLQRMDSIGT-TCSSK 705

  Fly   773 TRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRL---------------------EQK 816
            ||.           .::||..|:.    |:.|:|:|..::|                     |::
 Worm   706 TRA-----------DSLRSVDSKG----SKKSNRNGIAVKLVKRAIKHEHSLKRKVSKAQRKEKR 755

  Fly   817 ATKVLGVVFFTFVILWSPFFVLNLLPTVCA-----ECEERISHWVFDVVTWLGYASSMVNPIFYT 876
            |||.||||...|::.|.||||:|:|..||.     .|:  :.:.:|...||:||.:|.:|||.||
 Worm   756 ATKTLGVVVGVFLVCWVPFFVINILNAVCILLNKDSCQ--VGYDLFFYCTWIGYMNSFMNPIIYT 818

  Fly   877 IFNKVFRQAFKKVLLCRYSS 896
            |||..||:|||.::..|.|:
 Worm   819 IFNTEFRRAFKSIIFGRNST 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	60/214 (28%)
		TM helix 1	75..101	CDD:320433	9/25 (36%)
		TM helix 2	108..134	CDD:320433	10/25 (40%)
		TM helix 3	146..176	CDD:320433	13/29 (45%)
		TM helix 4	188..211	CDD:320433	7/22 (32%)
		TM helix 5	229..258	CDD:320433	6/28 (21%)
		7tm_GPCRs	<799..893	CDD:475119	43/119 (36%)
		TM helix 6	818..840	CDD:410628	12/21 (57%)
		TM helix 7	854..879	CDD:410628	12/24 (50%)
dop-2	NP_001256126.1	7tmA_D2-like_dopamine_R	38..>233	CDD:320181	59/196 (30%)
		TM helix 1	39..65	CDD:320181	9/25 (36%)
		TM helix 2	72..98	CDD:320181	10/25 (40%)
		TM helix 3	111..141	CDD:320181	13/29 (45%)
		TM helix 4	154..177	CDD:320181	7/24 (29%)
		TM helix 5	194..223	CDD:320181	6/28 (21%)
		7tm_GPCRs	<745..828	CDD:475119	35/84 (42%)
		TM helix 6	757..779	CDD:410628	12/21 (57%)
		TM helix 7	796..821	CDD:410628	12/24 (50%)