Protein Alignment 5-HT2B and ser-4

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: NP_497452.1
• Gene: ser-4 / 175322
• WormBaseID: WBGene00004779
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 836
• Identity: 145/836 - (17%)
• Similarity: 233/836 - (27%)
• Gaps: 444/836 - (53%)

  Fly    65 FEDV--PFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLM-SLAITDLMVAVLV 126
            |.|:  |.......|.:.|||:|....||:.|.|||..||.|:....|:|: |||:.||:|.::|
 Worm    41 FSDIERPLVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIV 105

  Fly   127 MPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVT 191
            .|||....|.|.:.||...|..||.:|||.|||||:||..|::|||.|:. .:.:.:|:|.:|:|
 Worm   106 TPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSIT-DICYVQNRTPKRIT 169

  Fly   192 LKIVFVWLLSIAMSL-PLSLMYSKNHAS-VLVNGTCQIPDPV-YKLVGSIVCFYIPLGVMLLTYC 253
            |.:..:|..|:.:|| |.:....:..:. ||.:..|.|...: |::..:...|||||..::..|.
 Worm   170 LMLAVIWFTSLLISLAPFAGWKDEGFSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAIICVYW 234

  Fly   254 LTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANS 318
            ..:| .|::|                          .:|....|.:::|.|
 Worm   235 KIMR-AAKKR--------------------------FKRERDRRTVIRPPP-------------- 258

  Fly   319 TDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLS 383
                 ..:|..:..:|..|.|.|.|..:.               :..:.::..||..|.|
 Worm   259 -----DAIDEKKAMMPKKSKKCPLPPAVV---------------ISDIQANGGTGGKTNS----- 298

  Fly   384 NHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRN 448
                                                                             
 Worm   299 ----------------------------------------------------------------- 298

  Fly   449 SLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRH 513
                                                               ::.|
 Worm   299 ---------------------------------------------------IKNP---------- 302

  Fly   514 NSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQ 578
                     |||            .|..|:..::::|.::..|:.
 Worm   303 ---------PRH------------NESSSSASEEERTMTQTNHAP-------------------- 326

  Fly   579 SDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSL 643
                           ||                    |||..|.:...
 Worm   327 ---------------GD--------------------VTTQETKIDEE----------------- 339

  Fly   644 TSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTA 708
                                                                 .||.|..|.|
 Worm   340 -----------------------------------------------------NGRSKPGIVK-- 349

  Fly   709 SVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKT 773
                                                     ||..|..|::
 Worm   350 -----------------------------------------RRRRTKESNE-------------- 359

  Fly   774 RTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVL 838
                                                 ::.|:||.:.|.::..|||..|:|||::
 Worm   360 -------------------------------------MKRERKAWRTLAIITGTFVACWTPFFLV 387

  Fly   839 NLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL--LC 892
            ::...:|. |:  ||..:..|..||||.:|.:|||.||:|::.||.|||:::  :|
 Worm   388 SIYRPICG-CQ--ISPVLEQVTLWLGYLNSALNPIIYTVFSQDFRAAFKRIIKRMC 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	72/196 (37%)
		TM helix 1	75..101	CDD:320433	11/25 (44%)
		TM helix 2	108..134	CDD:320433	12/26 (46%)
		TM helix 3	146..176	CDD:320433	18/29 (62%)
		TM helix 4	188..211	CDD:320433	8/23 (35%)
		TM helix 5	229..258	CDD:320433	7/29 (24%)
		7tm_GPCRs	<799..893	CDD:475119	33/96 (34%)
		TM helix 6	818..840	CDD:410628	8/21 (38%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	138/815 (17%)
		TM helix 1	53..79	CDD:320454	11/25 (44%)
		TM helix 2	87..113	CDD:320454	12/25 (48%)
		TM helix 3	125..155	CDD:320454	18/29 (62%)
		TM helix 4	166..188	CDD:320454	8/21 (38%)
		TM helix 5	210..239	CDD:320454	8/29 (28%)
		TM helix 6	361..391	CDD:320454	11/29 (38%)
		TM helix 7	400..425	CDD:320454	11/24 (46%)