DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr7

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001334371.1 Gene:Htr7 / 15566 MGIID:99841 Length:470 Species:Mus musculus


Alignment Length:410 Identity:112/410 - (27%)
Similarity:173/410 - (42%) Gaps:117/410 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 WNATGNATISATFEDVPFDANNY--------WALLALVLVLGTAAGNILVCLAIAWERRLQNVTN 109
            |:|..: .:|...|.:     ||        .::|.|:.:| |.|||.||.:::.:.::|:..:|
Mouse    63 WDAPPD-NVSGCGEQI-----NYGRVEKVVIGSILTLITLL-TIAGNCLVVISVCFVKKLRQPSN 120

  Fly   110 YFLMSLAITDLMVAVLVMP-LGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYL 173
            |.::|||:.||.|||.||| :.:..|:.|.:..|...|..:|.:||:.||||||.||.||:||||
Mouse   121 YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYL 185

  Fly   174 SLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNG--TCQI-PDPVYKLV 235
            .:..|:.:...:..:.:...|:.|||||.:::||....:::|     ||.  .|.| .|..|.:.
Mouse   186 GITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQN-----VNDDKVCLISQDFGYTIY 245

  Fly   236 GSIVCFYIPLGVMLLTY------------------------------------------CLTV-R 257
            .:.|.||||:.|||..|                                          |..: |
Mouse   246 STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQKEVEECANLSR 310

  Fly   258 LLARQRQNLG--GGQQTAAATPGWASG-----WL-------------GQAPA-----LERRCTWR 297
            ||..:|:|:.  ..:|.||.|.|...|     ||             |.:.:     :||.|.|.
Mouse   311 LLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWL 375

  Fly   298 RLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRG 362
                   |.|:|:::.......:.||.|.....|.....:|..  ..:...:|    |.|||:. 
Mouse   376 -------GYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR--KLSAAGMH----EALKLAE- 426

  Fly   363 LESVASSSTTGSPTKSEFSL 382
                       .|.:|||.|
Mouse   427 -----------RPERSEFVL 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 77/247 (31%)
TM helix 1 75..101 CDD:320433 10/33 (30%)
TM helix 2 108..134 CDD:320433 13/26 (50%)
TM helix 3 146..176 CDD:320433 18/29 (62%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 12/71 (17%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
Htr7NP_001334371.1 7tmA_5-HT7 100..398 CDD:320452 90/309 (29%)
TM helix 2 119..145 CDD:320452 13/25 (52%)
TM helix 3 158..188 CDD:320452 18/29 (62%)
TM helix 4 200..222 CDD:320452 8/21 (38%)
TM helix 5 239..268 CDD:320452 11/28 (39%)
TM helix 6 323..353 CDD:320452 8/29 (28%)
TM helix 7 366..391 CDD:320452 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

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