DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 5-HT2B and Htr2b

DIOPT Version :9

Sequence 1:	NP_001262373.1	Gene:	5-HT2B / 41017	FlyBaseID:	FBgn0261929	Length:	947	Species:	Drosophila melanogaster
Sequence 2:	XP_006529209.1	Gene:	Htr2b / 15559	MGIID:	109323	Length:	495	Species:	Mus musculus

Alignment Length:	967	Identity:	178/967 - (18%)
Similarity:	273/967 - (28%)	Gaps:	558/967 - (57%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISATFE---DVPFDANN-YW-ALLA 80
            ::|||::       |:|..         |:...|.:|..|.|...|   .|....:. :| |||.
Mouse    12 TTSEHIL-------QKTCD---------HLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLI 60

  Fly    81 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLV-KGYFPLGSE 144
            |.:::.|..|||||.||:|.|:|||..||||||||||.||:|.:.|||:.:||:: :..:||...
Mouse    61 LAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLA 125

  Fly   145 HCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM-SLPL 208
            .|..|:.|||||.||||||||.||:|||::::.|::..:..:|....:||..|||:||.| .:||
Mouse   126 LCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGMWGMPL 190

  Fly   209 SLMYSKNHASVLV----------------NGTCQIPDP---VYKLVGSIVCFYIPLGVMLLTYCL 254
             ..|.:|.:|.:.                |.||::...   .:.:.||:..|:.||.:|::||.|
Mouse   191 -FPYGQNASSGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFL 254

  Fly   255 TVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANST 319
            |:..|.::..                                  |:|..|
Mouse   255 TIHTLQKKAY----------------------------------LVKNKP--------------- 270

  Fly   320 DTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSN 384

Mouse   271 ----------------------------------------------------------------- 270

  Fly   385 HLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNS 449
                     |||                                     |:..|:
Mouse   271 ---------PQR-------------------------------------LTRWTV---------- 279

  Fly   450 LASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHN 514
                                                                 ||..||.
Mouse   280 -----------------------------------------------------PTVFLRE----- 286

  Fly   515 SLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQS 579

Mouse   287 ----------------------------------------------------------------- 286

  Fly   580 DYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644
                                           .|:|          |||.::.:|
Mouse   287 -------------------------------DSSF----------SSPEKVAML----------- 299

  Fly   645 SSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTAS 709
                                                   |||
Mouse   300 ---------------------------------------DGS----------------------- 302

  Fly   710 VVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTR 774
                    ||                 .|....|:..|.:||.:::               ||
Mouse   303 --------HR-----------------DKILPNSSDETLMRRMSSV---------------GK-- 325

  Fly   775 TTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLN 839
                                |::..||.           ||:|:|.||||||.|:::|.|||:.|
Mouse   326 --------------------RSAQTISN-----------EQRASKALGVVFFLFLLMWCPFFITN 359

  Fly   840 LLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWR--- 901
            |...:|..|.:.....:.::..|:||.||.|||:.||:|||.||:||.:.:.|.|.:|.:.:
Mouse   360 LTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALR 424

  Fly   902 -----------------------------PSRXQTPVKPGKLKTNTHKCASVDFQDS 929
                                         |:. |:|:   :|:::|.:.:|:...|:
Mouse   425 KFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPM---RLRSSTIQSSSIILLDT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	81/192 (42%)
5-HT2B	NP_001262373.1	7tm_4	90..>238	CDD:304433	71/168 (42%)
Htr2b	XP_006529209.1	7tm_GPCRs	54..413	CDD:391938	156/839 (19%)
		TM helix 1	55..81	CDD:341315	14/25 (56%)
		TM helix 2	88..114	CDD:341315	17/25 (68%)
		TM helix 3	127..157	CDD:341315	20/29 (69%)
		TM helix 4	169..208	CDD:341315	13/39 (33%)
		TM helix 5	229..258	CDD:341315	10/28 (36%)
		TM helix 6	332..362	CDD:341315	18/40 (45%)
		TM helix 7	374..399	CDD:341315	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X759
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.050