DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr2a

DIOPT Version :9

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_766400.1 Gene:Htr2a / 15558 MGIID:109521 Length:471 Species:Mus musculus


Alignment Length:915 Identity:171/915 - (18%)
Similarity:250/915 - (27%) Gaps:532/915 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 NDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISAT-FEDVPFDANNYW 76
            ||....|.::|| ...|..|...||                |.:....:..| ...:.....|:.
Mouse    30 NDFNSRDANTSE-ASNWTIDAENRT----------------NLSCEGYLPPTCLSILHLQEKNWS 77

  Fly    77 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FP 140
            |||..|:::.|.||||||.:|::.|::|||.||||||||||.|:::..||||:.:||::.|| :|
Mouse    78 ALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWP 142

  Fly   141 LGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS 205
            |.|:.|..||.|||||.||||||||.||:|||::::.|:...|..:|.:..|||:.||.:|:.:|
Mouse   143 LPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGIS 207

  Fly   206 LPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQ 270
            :|:.:...::.:.|...|:|.:.|..:.|:||.|.|:|||.:|::||.||::.|.::        
Mouse   208 MPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKE-------- 264

  Fly   271 QTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPD 335
                                                                             
Mouse   265 ----------------------------------------------------------------- 264

  Fly   336 SSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAAT 400
                                                                             
Mouse   265 ----------------------------------------------------------------- 264

  Fly   401 HQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLS 465
                                                .||.:...|||..|:|           .|
Mouse   265 ------------------------------------ATLCVSDLSTRAKLSS-----------FS 282

  Fly   466 QLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQE 530
            .|.|                                            :||....|:.|      
Mouse   283 FLPQ--------------------------------------------SSLSSEKLFQR------ 297

  Fly   531 SLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595
                                                                             
Mouse   298 ----------------------------------------------------------------- 297

  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660
                                                                             
Mouse   298 ----------------------------------------------------------------- 297

  Fly   661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725
                                                                   |.||..||..
Mouse   298 -------------------------------------------------------SIHREPGSYA 307

  Fly   726 GGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVR 790
            |                       ||  |::|..|                              
Mouse   308 G-----------------------RR--TMQSISN------------------------------ 317

  Fly   791 SHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISH 854
                                   ||||.||||:|||.||::|.|||:.|::..:|.| |.|.:..
Mouse   318 -----------------------EQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIG 359

  Fly   855 WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS--------------TSAWRPSRX 905
            .:.:|..|:||.||.|||:.||:|||.:|.||.:.:.|:|..              |.|::.|: 
Mouse   360 ALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQL 424

  Fly   906 QTPVK 910
            |...|
Mouse   425 QVGQK 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tm_1 90..>262 CDD:278431 82/172 (48%)
7tm_4 90..>238 CDD:304433 70/148 (47%)
Htr2aNP_766400.1 7tm_4 89..>207 CDD:304433 63/117 (54%)
7tm_1 91..380 CDD:278431 138/786 (18%)
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 155..160 4/4 (100%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 336..340 2/3 (67%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I2062
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 288 1.000 Inparanoid score I2804
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D408957at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_109260
Panther 1 1.100 - - O PTHR24247
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X759
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.970

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