Sequence 1: | NP_001262373.1 | Gene: | 5-HT2B / 41017 | FlyBaseID: | FBgn0261929 | Length: | 947 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_766400.1 | Gene: | Htr2a / 15558 | MGIID: | 109521 | Length: | 471 | Species: | Mus musculus |
Alignment Length: | 915 | Identity: | 171/915 - (18%) |
---|---|---|---|
Similarity: | 250/915 - (27%) | Gaps: | 532/915 - (58%) |
- Green bases have known domain annotations that are detailed below.
Fly 13 NDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISAT-FEDVPFDANNYW 76
Fly 77 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FP 140
Fly 141 LGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS 205
Fly 206 LPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQ 270
Fly 271 QTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPD 335
Fly 336 SSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAAT 400
Fly 401 HQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLS 465
Fly 466 QLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQE 530
Fly 531 SLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595
Fly 596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660
Fly 661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725
Fly 726 GGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVR 790
Fly 791 SHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISH 854
Fly 855 WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS--------------TSAWRPSRX 905
Fly 906 QTPVK 910 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
5-HT2B | NP_001262373.1 | 7tm_1 | 90..>262 | CDD:278431 | 82/172 (48%) |
7tm_4 | 90..>238 | CDD:304433 | 70/148 (47%) | ||
Htr2a | NP_766400.1 | 7tm_4 | 89..>207 | CDD:304433 | 63/117 (54%) |
7tm_1 | 91..380 | CDD:278431 | 138/786 (18%) | ||
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 | 155..160 | 4/4 (100%) | |||
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 | 172..174 | 1/1 (100%) | |||
Agonist binding. /evidence=ECO:0000250|UniProtKB:P41595 | 336..340 | 2/3 (67%) | |||
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 | 376..380 | 2/3 (67%) | |||
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 | 469..471 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 253 | 1.000 | Domainoid score | I2062 |
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 288 | 1.000 | Inparanoid score | I2804 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D408957at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_109260 | |
Panther | 1 | 1.100 | - | - | O | PTHR24247 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X759 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
8 | 7.970 |