DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Htr2a

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_766400.1 Gene:Htr2a / 15558 MGIID:109521 Length:471 Species:Mus musculus


Alignment Length:915 Identity:171/915 - (18%)
Similarity:250/915 - (27%) Gaps:532/915 - (58%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 NDSGGDDWSSSEHLVLWEEDETQRTTANATSRHNQLHVARWNATGNATISAT-FEDVPFDANNYW 76
            ||....|.::|| ...|..|...||                |.:....:..| ...:.....|:.
Mouse    30 NDFNSRDANTSE-ASNWTIDAENRT----------------NLSCEGYLPPTCLSILHLQEKNWS 77

  Fly    77 ALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FP 140
            |||..|:::.|.||||||.:|::.|::|||.||||||||||.|:::..||||:.:||::.|| :|
Mouse    78 ALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWP 142

  Fly   141 LGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS 205
            |.|:.|..||.|||||.||||||||.||:|||::::.|:...|..:|.:..|||:.||.:|:.:|
Mouse   143 LPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGIS 207

  Fly   206 LPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQ 270
            :|:.:...::.:.|...|:|.:.|..:.|:||.|.|:|||.:|::||.||::.|.::        
Mouse   208 MPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKE-------- 264

  Fly   271 QTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPD 335
                                                                             
Mouse   265 ----------------------------------------------------------------- 264

  Fly   336 SSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAAT 400
                                                                             
Mouse   265 ----------------------------------------------------------------- 264

  Fly   401 HQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLS 465
                                                .||.:...|||..|:|           .|
Mouse   265 ------------------------------------ATLCVSDLSTRAKLSS-----------FS 282

  Fly   466 QLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQE 530
            .|.|                                            :||....|:.|      
Mouse   283 FLPQ--------------------------------------------SSLSSEKLFQR------ 297

  Fly   531 SLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGD 595
                                                                             
Mouse   298 ----------------------------------------------------------------- 297

  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAP 660
                                                                             
Mouse   298 ----------------------------------------------------------------- 297

  Fly   661 ATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSF 725
                                                                   |.||..||..
Mouse   298 -------------------------------------------------------SIHREPGSYA 307

  Fly   726 GGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVR 790
            |                       ||  |::|..|                              
Mouse   308 G-----------------------RR--TMQSISN------------------------------ 317

  Fly   791 SHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISH 854
                                   ||||.||||:|||.||::|.|||:.|::..:|.| |.|.:..
Mouse   318 -----------------------EQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIG 359

  Fly   855 WVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSS--------------TSAWRPSRX 905
            .:.:|..|:||.||.|||:.||:|||.:|.||.:.:.|:|..              |.|::.|:.
Mouse   360 ALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQL 424

  Fly   906 QTPVK 910
            |...|
Mouse   425 QVGQK 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 89/193 (46%)
TM helix 1 75..101 CDD:320433 12/25 (48%)
TM helix 2 108..134 CDD:320433 16/25 (64%)
TM helix 3 146..176 CDD:320433 21/29 (72%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 14/28 (50%)
7tm_GPCRs <799..893 CDD:475119 39/94 (41%)
TM helix 6 818..840 CDD:410628 13/21 (62%)
TM helix 7 854..879 CDD:410628 11/24 (46%)
Htr2aNP_766400.1 7tmA_5-HT2A 75..391 CDD:341345 151/813 (19%)
TM helix 1 76..102 CDD:341345 12/25 (48%)
TM helix 2 109..135 CDD:341345 16/25 (64%)
TM helix 3 148..178 CDD:341345 21/29 (72%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 8/22 (36%)
TM helix 5 231..260 CDD:341345 14/28 (50%)
TM helix 6 316..346 CDD:341345 19/82 (23%)
TM helix 7 359..384 CDD:341345 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P28223 469..471
Blue background indicates that the domain is not in the aligned region.

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