DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ADRB3

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000016.1 Gene:ADRB3 / 155 HGNCID:288 Length:408 Species:Homo sapiens


Alignment Length:275 Identity:97/275 - (35%)
Similarity:135/275 - (49%) Gaps:33/275 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 HNQLHVARW----NATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQ 105
            |....:|.|    ....|...::....||::|....|||||. ||.|..||:||.:||||..|||
Human     6 HENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALA-VLATVGGNLLVIVAIAWTPRLQ 69

  Fly   106 NVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVD 170
            .:||.|:.|||..||::.:||:|......:.|::|||:..|..|..:|||..||||..||.::||
Human    70 TMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVD 134

  Fly   171 RYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKNHASVLV-----NGTC---- 225
            |||::..|:|:|...|:|.....:|.||::|.|:|. |:...:.:..|....     |..|    
Human   135 RYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFA 199

  Fly   226 -QIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPA 289
             .:|   |.|:.|.|.||:||.|||..|.....:..||.:.|              .|.||:.|.
Human   200 SNMP---YVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLL--------------RGELGRFPP 247

  Fly   290 LERRCTWRRLLKPGP 304
            .|......|.|.|.|
Human   248 EESPPAPSRSLAPAP 262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 80/203 (39%)
TM helix 1 75..101 CDD:320433 15/25 (60%)
TM helix 2 108..134 CDD:320433 11/25 (44%)
TM helix 3 146..176 CDD:320433 16/29 (55%)
TM helix 4 188..211 CDD:320433 8/23 (35%)
TM helix 5 229..258 CDD:320433 12/28 (43%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
ADRB3NP_000016.1 7tm_GPCRs 51..356 CDD:475119 83/229 (36%)
TM helix 2 73..95 CDD:320625 10/21 (48%)
TM helix 3 111..133 CDD:320625 10/21 (48%)
TM helix 4 156..172 CDD:320625 6/15 (40%)
TM helix 5 202..225 CDD:320625 12/25 (48%)
TM helix 6 291..313 CDD:320625
TM helix 7 325..350 CDD:320625
Blue background indicates that the domain is not in the aligned region.

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