DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ADRA2C

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:837 Identity:164/837 - (19%)
Similarity:231/837 - (27%) Gaps:440/837 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 FDANNYWALLALV--LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGIL 132
            :.|.....|.|:|  |::.|..||:||.:|:...|.|:...|.||:|||..|::||.||||..:.
Human    46 YSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLA 110

  Fly   133 TLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFV 197
            ..:..|:..|...|..::.|||||||:||:|||.||:|||.|:...:.:...:|.|||...||.|
Human   111 NELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAV 175

  Fly   198 WLLSIAMSLP--LSLMYSKNHASVLVNGTCQIPDPVYKLVGSIV-CFYIPLGVMLLTYC------ 253
            ||:|..:|.|  :||....:.|:.   ..|.:.|..:.::.|.: .|:.|..:|.|.|.      
Human   176 WLISAVISFPPLVSLYRQPDGAAY---PQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVA 237

  Fly   254 -LTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSAN 317
             |..|.|:.:|                       ||.             ||..||         
Human   238 KLRTRTLSEKR-----------------------APV-------------GPDGAS--------- 257

  Fly   318 STDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSL 382
                                     |||              ..||.:.|.:...|         
Human   258 -------------------------PTT--------------ENGLGAAAGAGENG--------- 274

  Fly   383 SNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTR 447
                   :.:.|                  ||.|                           |...
Human   275 -------HCAPP------------------PADV---------------------------EPDE 287

  Fly   448 NSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKR 512
            :|.|:.|                      |||..:...|..:|||.|                  
Human   288 SSAAAER----------------------RRRRGALRRGGRRRAGAE------------------ 312

  Fly   513 HNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNH 577
                                                                             
Human   313 ----------------------------------------------------------------- 312

  Fly   578 QSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKS 642
                                                                             
Human   313 ----------------------------------------------------------------- 312

  Fly   643 LTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKT 707
                      ||..||.    |....|.:|.            ||.|.|..:|.||.| ||.:.:
Human   313 ----------GGAGGAD----GQGAGPGAAE------------SGALTASRSPGPGGR-LSRASS 350

  Fly   708 ASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGK 772
            .||..:.|.|.|.|                       ||...|:.|..|                
Human   351 RSVEFFLSRRRRAR-----------------------SSVCRRKVAQAR---------------- 376

  Fly   773 TRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFV 837
                                                     |::.|.||.||...||:.|.|||.
Human   377 -----------------------------------------EKRFTFVLAVVMGVFVLCWFPFFF 400

  Fly   838 LNLLPTVCAE-CEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 893
            ...|..:|.| |:  :...:|....|:||.:|.:||:.||:||:.||::||.:|..|
Human   401 SYSLYGICREACQ--VPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRR 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 73/204 (36%)
TM helix 1 75..101 CDD:320433 10/27 (37%)
TM helix 2 108..134 CDD:320433 13/25 (52%)
TM helix 3 146..176 CDD:320433 19/29 (66%)
TM helix 4 188..211 CDD:320433 12/24 (50%)
TM helix 5 229..258 CDD:320433 8/36 (22%)
7tm_GPCRs <799..893 CDD:475119 32/94 (34%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 9/24 (38%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 156/814 (19%)
TM helix 2 86..112 CDD:320446 13/25 (52%)
TM helix 3 124..154 CDD:320446 19/29 (66%)
TM helix 4 166..189 CDD:320446 11/22 (50%)
TM helix 5 207..236 CDD:320446 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 46/442 (10%)
TM helix 6 375..405 CDD:320446 13/86 (15%)
TM helix 7 416..441 CDD:320446 9/24 (38%)

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