DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ADRA2A

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_000672.3 Gene:ADRA2A / 150 HGNCID:281 Length:465 Species:Homo sapiens


Alignment Length:869 Identity:166/869 - (19%)
Similarity:239/869 - (27%) Gaps:462/869 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ARWNAT----GNATISATFEDVPFDANNYWALLAL--VLVLGTAAGNILVCLAIAWERRLQNVTN 109
            |.||.|    |.|..:      |:.......|:.|  :|:|.|..||:||.:|:...|.|:...|
Human    26 ASWNGTEAPGGGARAT------PYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQN 84

  Fly   110 YFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLS 174
            .||:|||..|::||.||:|..:...|.||:..|...|..::.|||||||:||:|||.||:|||.|
Human    85 LFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWS 149

  Fly   175 LRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNG------TCQIPDPVYK 233
            :...:.:...:|.||:...|:.||::|..:|.|..:...|....   .|      .|:|.|..:.
Human   150 ITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGG---GGPQPAEPRCEINDQKWY 211

  Fly   234 LVGSIV-CFYIPLGVMLLTYCLTVRL--LARQRQNL---GGGQQTAAATPGWASGWLGQAPALER 292
            ::.|.: .|:.|..:|:|.|   ||:  :|::|..:   ..|....||.||          ..||
Human   212 VISSCIGSFFAPCLIMILVY---VRIYQIAKRRTRVPPSRRGPDAVAAPPG----------GTER 263

  Fly   293 RCTWRRLLKP----GPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFG 353
            |...   |.|    |||.|.:                              ||.||.:       
Human   264 RPNG---LGPERSAGPGGAEA------------------------------EPLPTQL------- 288

  Fly   354 AEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATH-QQSHHHNHQQHPAGVY 417
                           :...|.|.              |:.|:...|.. ::|...:|.:.|.|..
Human   289 ---------------NGAPGEPA--------------PAGPRDTDALDLEESSSSDHAERPPGPR 324

  Fly   418 HQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASS 482
            ..:..|:|                                                 |.:.|||.
Human   325 RPERGPRG-------------------------------------------------KGKARASQ 340

  Fly   483 AVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKD 547
            ..||                           :|||:.                            
Human   341 VKPG---------------------------DSLPRR---------------------------- 350

  Fly   548 QQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISS 612
                                                                             
Human   351 ----------------------------------------------------------------- 350

  Fly   613 AFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGS 677
                                                     ||        |:|           
Human   351 -----------------------------------------GP--------GAT----------- 355

  Fly   678 SLTVQSDGSGYLAAPGTPC--PGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTA 740
                         ..|||.  ||..::..:|.:   .|                           
Human   356 -------------GIGTPAAGPGEERVGAAKAS---RW--------------------------- 377

  Fly   741 TTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSS 805
                           |..||.                                            
Human   378 ---------------RGRQNR-------------------------------------------- 383

  Fly   806 RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTV-CAECEERISHWVFDVVTWLGYASSM 869
                    |::.|.||.||...||:.|.|||....|..| |:     :...:|....|.||.:|.
Human   384 --------EKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS-----VPRTLFKFFFWFGYCNSS 435

  Fly   870 VNPIFYTIFNKVFRQAFKKVLLCR 893
            :||:.|||||..||:||||: |||
Human   436 LNPVIYTIFNHDFRRAFKKI-LCR 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 71/206 (34%)
TM helix 1 75..101 CDD:320433 10/27 (37%)
TM helix 2 108..134 CDD:320433 12/25 (48%)
TM helix 3 146..176 CDD:320433 19/29 (66%)
TM helix 4 188..211 CDD:320433 8/22 (36%)
TM helix 5 229..258 CDD:320433 8/29 (28%)
7tm_GPCRs <799..893 CDD:475119 34/94 (36%)
TM helix 6 818..840 CDD:410628 11/21 (52%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
ADRA2ANP_000672.3 7tmA_alpha2A_AR 49..452 CDD:320445 152/831 (18%)
TM helix 1 50..76 CDD:320445 10/25 (40%)
TM helix 2 83..109 CDD:320445 12/25 (48%)
TM helix 3 121..151 CDD:320445 19/29 (66%)
TM helix 4 163..186 CDD:320445 8/22 (36%)
TM helix 5 208..237 CDD:320445 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..368 47/446 (11%)
PHA03307 244..>389 CDD:223039 53/562 (9%)
TM helix 6 382..412 CDD:320445 13/81 (16%)
TM helix 7 420..445 CDD:320445 10/24 (42%)

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