DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ADRA1A

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_150646.3 Gene:ADRA1A / 148 HGNCID:277 Length:475 Species:Homo sapiens


Alignment Length:425 Identity:110/425 - (25%)
Similarity:173/425 - (40%) Gaps:111/425 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 TGNATISATFEDVPFDANNYWALLALV----LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLA 116
            :|||:.|:.....|...|...|:|..|    |:|....|||||.|::|..|.|.:||:|::::||
Human     5 SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLA 69

  Fly   117 ITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF 181
            :.||::...|:|...:..|.||:..|...|..|..:|||.||||||.||.||:|||:.:.||:|:
Human    70 VADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRY 134

  Fly   182 GRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKNHASVLVNGTCQI-PDPVYKLVGSIVCFYIP 244
            ....|:||..:.::.||.||:.:|: ||   :.....:......||| .:|.|.|..::..||:|
Human   135 PTIVTQRRGLMALLCVWALSLVISIGPL---FGWRQPAPEDETICQINEEPGYVLFSALGSFYLP 196

  Fly   245 LGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASS 309
            |.::|:.||....:..|:.:.|..|.:|                                     
Human   197 LAIILVMYCRVYVVAKRESRGLKSGLKT------------------------------------- 224

  Fly   310 VLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTG- 373
                   :.:|::..||..|....|.......:..|.|   .|...:||.||   ...::.|.| 
Human   225 -------DKSDSEQVTLRIHRKNAPAGGSGMASAKTKT---HFSVRLLKFSR---EKKAAKTLGI 276

  Fly   374 -------------------------SPTKSEFSLSNHL--------QLQYPSSPQRYAATHQ--- 402
                                     .|:::.|.:...|        .:.||.|.|.:....|   
Human   277 VVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

  Fly   403 --------QSHHH--NHQQHPAGVYHQQASPKGRH 427
                    ||..|  .:..||     ...:.:|:|
Human   342 RIQCLCRKQSSKHALGYTLHP-----PSQAVEGQH 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 72/198 (36%)
TM helix 1 75..101 CDD:320433 12/29 (41%)
TM helix 2 108..134 CDD:320433 8/25 (32%)
TM helix 3 146..176 CDD:320433 18/29 (62%)
TM helix 4 188..211 CDD:320433 9/23 (39%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
ADRA1ANP_150646.3 7tmA_alpha1A_AR 27..337 CDD:320448 95/362 (26%)
TM helix 1 28..54 CDD:320448 11/25 (44%)
TM helix 2 61..87 CDD:320448 8/25 (32%)
TM helix 3 99..129 CDD:320448 18/29 (62%)
TM helix 4 141..164 CDD:320448 9/25 (36%)
TM helix 5 181..210 CDD:320448 10/28 (36%)
TM helix 6 265..295 CDD:320448 4/32 (13%)
TM helix 7 305..330 CDD:320448 4/24 (17%)
Nuclear localization signal 334..349 1/14 (7%)
Blue background indicates that the domain is not in the aligned region.

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