DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and ADRA1B

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:XP_011532737.1 Gene:ADRA1B / 147 HGNCID:278 Length:556 Species:Homo sapiens


Alignment Length:326 Identity:96/326 - (29%)
Similarity:147/326 - (45%) Gaps:55/326 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 HNQLHVARWNATGNATISA---TFEDVPFDANNYWALLALVLVLG-----TAAGNILVCLAIAWE 101
            ||....|.|....||..:.   |..:......:....:::.||||     ...|||||.|::|..
Human     9 HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACN 73

  Fly   102 RRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCT 166
            |.|:..||||:::||:.||:::..|:|......|.||:.||...|..|..:|||.|||||:.||.
Human    74 RHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCA 138

  Fly   167 ISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQI-PDP 230
            ||:|||:.:||.:::....|||:..|.::.||:||..:|:...|.:.:...:  .:..|.: .:|
Human   139 ISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPN--DDKECGVTEEP 201

  Fly   231 VYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCT 295
            .|.|..|:..|||||.|:|:.||....:..|..:||..|                          
Human   202 FYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG-------------------------- 240

  Fly   296 WRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLS 360
               ::|....:....|..||.|.          ||..|..:..|...|.:..|:     ::.|.|
Human   241 ---VMKEMSNSKELTLRIHSKNF----------HEDTLSSTKAKGHNPRSSIAV-----KLFKFS 287

  Fly   361 R 361
            |
Human   288 R 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 73/198 (37%)
TM helix 1 75..101 CDD:320433 11/30 (37%)
TM helix 2 108..134 CDD:320433 10/25 (40%)
TM helix 3 146..176 CDD:320433 17/29 (59%)
TM helix 4 188..211 CDD:320433 7/22 (32%)
TM helix 5 229..258 CDD:320433 13/28 (46%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
ADRA1BXP_011532737.1 7tmA_alpha1B_AR 46..395 CDD:320449 89/289 (31%)
TM helix 1 47..73 CDD:320449 11/25 (44%)
TM helix 2 80..106 CDD:320449 10/25 (40%)
TM helix 3 118..148 CDD:320449 17/29 (59%)
TM helix 4 160..183 CDD:320449 7/22 (32%)
TM helix 5 200..229 CDD:320449 13/28 (46%)
TM helix 6 287..353 CDD:320449 2/2 (100%)
TM helix 7 363..388 CDD:320449
Blue background indicates that the domain is not in the aligned region.

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