DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and TAAR1

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_612200.1 Gene:TAAR1 / 134864 HGNCID:17734 Length:339 Species:Homo sapiens


Alignment Length:235 Identity:58/235 - (24%)
Similarity:111/235 - (47%) Gaps:49/235 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 VPFDAN--------NYWA--------LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLA 116
            :||..|        |.|:        .|.::::|.|..||::|.::|:..::|...||:.:.|:|
Human     2 MPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMA 66

  Fly   117 ITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRF 181
            ..|.::..||||..::...:..:..|...|......|::..:|||.||..||:|||.::..|:|:
Human    67 TVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRY 131

  Fly   182 GRNKTRRRVTLKIVFVWLLSIAMSLP---------LSL-------MYSKNHASVLVNGTCQIPDP 230
                 :.::.:.::.| ::.|:.|:|         |.|       :|.|:   |...|.|.:   
Human   132 -----KAKMNILVICV-MIFISWSVPAVFAFGMIFLELNFKGAEEIYYKH---VHCRGGCSV--- 184

  Fly   231 VYKLVGSIV----CFYIPLGVMLLTYCLTVRLLARQRQNL 266
            .:..:..::    .||||..:||..| ..:.|:|:::..|
Human   185 FFSKISGVLTFMTSFYIPGSIMLCVY-YRIYLIAKEQARL 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 55/221 (25%)
TM helix 1 75..101 CDD:320433 8/33 (24%)
TM helix 2 108..134 CDD:320433 9/25 (36%)
TM helix 3 146..176 CDD:320433 12/29 (41%)
TM helix 4 188..211 CDD:320433 6/38 (16%)
TM helix 5 229..258 CDD:320433 7/32 (22%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
TAAR1NP_612200.1 7tmA_TAAR1 26..315 CDD:320438 53/211 (25%)
TM helix 1 26..51 CDD:320438 7/24 (29%)
TM helix 2 58..84 CDD:320438 9/25 (36%)
TM helix 3 96..126 CDD:320438 12/29 (41%)
TM helix 4 138..161 CDD:320438 4/23 (17%)
Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465 175..186 3/16 (19%)
TM helix 5 187..216 CDD:320438 7/29 (24%)
TM helix 6 244..274 CDD:320438
TM helix 7 283..308 CDD:320438
Blue background indicates that the domain is not in the aligned region.

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